Microglia, the immune cells of the central nervous system, have long been a subject of study
in the Alzheimer's disease (AD) field due to their dramatic responses to the pathophysiology …

This review is directed at understanding how neuronal death occurs in two distinct insults,
global ischemia and focal ischemia. These are the two principal rodent models for human …

Neuronal and synaptic loss is characteristic in many neurodegenerative diseases, such as
frontotemporal dementia and Alzheimer's disease. Recently, we showed that inducing …

Microglia, the brain's resident macrophages, are incredibly plastic and dynamic cells. In this
chapter, we aim to describe and classify the many morphological changes they can display …

Focal cerebral ischemia elicits a strong inflammatory response involving early recruitment of
granulocytes and delayed infiltration of ischemic areas and the boundary zones by T cells …

Increased oxidative stress has been implicated in the mechanisms of delayed neuronal cell
death (DND) following cerebral ischemic insult. In this study, we investigated whether …

Brain injury, as occurs in stroke or head trauma, induces a dramatic increase in levels of
tumor necrosis factor–α (TNF), but its role in brain injury response is unknown. We …

We have injected lipopolysaccharide (LPS) into the nigrostriatal pathway of rats in order to
address the role of inflammation in Parkinson's disease (PD). LPS induced a strong …

Epileptogenesis refers to a process in which an initial brain-damaging insult triggers a
cascade of molecular and cellular changes that eventually lead to the occurrence of …

Reactive microgliosis is characteristic of trauma and stroke as well as inflammatory and
chronic neurodegenerative disease. A conspicuous feature of the microglial reaction to …