Cancer stem cells (CSCs) have emerged as key contributors to tumor initiation, growth, and
metastasis. In addition, CSCs play a significant role in inducing immune evasion, thereby …

Today, cancer treatment is one of the fundamental problems facing clinicians and
researchers worldwide. Efforts to find an excellent way to treat this illness continue, and new …

Abstract Cell-based immunotherapies (CBIs), notably exemplified by chimeric antigen
receptor (CAR)-engineered T (CAR-T) cell therapy, have emerged as groundbreaking …

The advent of chimeric antigen receptor T cells (CAR-T cells) has made a tremendous
revolution in the era of cancer immunotherapy, so that since 2017 eight CAR-T cell products …

Acute myeloid leukemia (AML) remains an elusive disease to treat, let alone cure, even after
highly intensive therapies such as stem cell transplants. Adoptive cell therapeutic strategies …

Invariant natural killer T (iNKT) cells are a unique T lymphocyte population expressing semi-
invariant T cell receptors (TCRs) that recognise lipid antigens presented by CD1d. iNKT …

Invariant natural killer T (iNKT) cells have the capacity to mount potent anti-tumor reactivity
and have therefore become a focus in the development of cell-based immunotherapy. iNKT …

Backgroud: Thymic atrophy marks the onset of immune aging, precipitating developmental
anomalies in T cells. Numerous clinical and preclinical investigations have underscored the …

Multiple Myeloma (MM) is a malignant growth of clonal plasma cells, typically arising from
asymptomatic precursor conditions, namely monoclonal gammopathy of undetermined …

After experiencing many ups and downs, chimeric antigen receptor (CAR)-T cell therapy has
reached a milestone as an anti-cancer method, as evidenced by the increasing number of …