Mechanisms of cellular invasion by intracellular parasites

DM Walker, S Oghumu, G Gupta, BS McGwire… - Cellular and molecular …, 2014 - Springer
Numerous disease-causing parasites must invade host cells in order to prosper.
Collectively, such pathogens are responsible for a staggering amount of human sickness …

Overlaying molecular and temporal aspects of malaria parasite invasion

GE Weiss, BS Crabb, PR Gilson - Trends in parasitology, 2016 - cell.com
A highly-effective, long-lasting vaccine, targeting multiple stages of the Plasmodium
falciparum life cycle, is likely to be important for the elimination of this pathogen. Key …

Revealing the Sequence and Resulting Cellular Morphology of Receptor-Ligand Interactions during Plasmodium falciparum Invasion of Erythrocytes

GE Weiss, PR Gilson, T Taechalertpaisarn… - PLoS …, 2015 - journals.plos.org
During blood stage Plasmodium falciparum infection, merozoites invade uninfected
erythrocytes via a complex, multistep process involving a series of distinct receptor-ligand …

Efficient backbone cyclization of linear peptides by a recombinant asparaginyl endopeptidase

KS Harris, T Durek, Q Kaas, AG Poth, EK Gilding… - Nature …, 2015 - nature.com
Cyclotides are diverse plant backbone cyclized peptides that have attracted interest as
pharmaceutical scaffolds, but fundamentals of their biosynthetic origin remain elusive …

Enantioselective direct α-amination of aldehydes via a photoredox mechanism: a strategy for asymmetric amine fragment coupling

G Cecere, CM König, JL Alleva… - Journal of the …, 2013 - ACS Publications
The direct, asymmetric α-amination of aldehydes has been accomplished via a combination
of photoredox and organocatalysis. Photon-generated N-centered radicals undergo …

Interaction between Plasmodium falciparum apical membrane antigen 1 and the rhoptry neck protein complex defines a key step in the erythrocyte invasion process of …

D Richard, CA MacRaild, DT Riglar, JA Chan… - Journal of Biological …, 2010 - ASBMB
Invasion of host cells by apicomplexan parasites, including Plasmodium falciparum and
Toxoplasma gondii, is a multistep process. Central to invasion is the formation of a tight …

Structural and functional insights into the malaria parasite moving junction complex

B Vulliez-Le Normand, ML Tonkin… - PLoS …, 2012 - journals.plos.org
Members of the phylum Apicomplexa, which include the malaria parasite Plasmodium,
share many features in their invasion mechanism in spite of their diverse host cell …

Survey of the 2009 commercial optical biosensor literature

RL Rich, DG Myszka - Journal of Molecular Recognition, 2011 - Wiley Online Library
We took a different approach to reviewing the commercial biosensor literature this year by
inviting 22 biosensor users to serve as a review committee. They set the criteria for what to …

AMA1 and MAEBL are important for Plasmodium falciparum sporozoite infection of the liver

ASP Yang, S Lopaticki, MT O'Neill… - Cellular …, 2017 - Wiley Online Library
The malaria sporozoite injected by a mosquito migrates to the liver by traversing host cells.
The sporozoite also traverses hepatocytes before invading a terminal hepatocyte and …

N-methylated α-amino acids and peptides: synthesis and biological activity

M Luisa Di Gioia, A Leggio, F Malagrinò… - Mini reviews in …, 2016 - ingentaconnect.com
The simplest and minimal modification of a single amino acid or peptide bonds is
represented by N-methylation. This can improve the pharmacokinetic properties of …