REASSURED diagnostics to inform disease control strategies, strengthen health systems and improve patient outcomes

KJ Land, DI Boeras, XS Chen, AR Ramsay… - Nature …, 2019 - nature.com
Lack of access to quality diagnostics remains a major contributor to health burden in
resource-limited settings. It has been more than 10 years since ASSURED (affordable …

Burden, pathology, and costs of malaria in pregnancy: new developments for an old problem

SJ Rogerson, M Desai, A Mayor, E Sicuri… - The Lancet infectious …, 2018 - thelancet.com
Over the past 10 years, knowledge of the burden, economic costs, and consequences of
malaria in pregnancy has improved, and the prevalence of malaria caused by Plasmodium …

Plasmodium falciparum is evolving to escape malaria rapid diagnostic tests in Ethiopia

SM Feleke, EN Reichert, H Mohammed… - Nature …, 2021 - nature.com
In Africa, most rapid diagnostic tests (RDTs) for falciparum malaria recognize histidine-rich
protein 2 antigen. Plasmodium falciparum parasites lacking histidine-rich protein 2 (pfhrp2) …

Changes in malaria epidemiology in Africa and new challenges for elimination

IN Nkumama, WP O'meara, FHA Osier - Trends in parasitology, 2017 - cell.com
Although the burden of Plasmodium falciparum malaria is gradually declining in many parts
of Africa, it is characterized by spatial and temporal variability that presents new and …

malERA: an updated research agenda for malaria elimination and eradication

RN Rabinovich, C Drakeley, AA Djimde, BF Hall… - PLoS …, 2017 - journals.plos.org
Achieving a malaria-free world presents exciting scientific challenges as well as
overwhelming health, equity, and economic benefits. WHO and countries are setting …

[HTML][HTML] An open dataset of Plasmodium falciparum genome variation in 7,000 worldwide samples

A Ahouidi, M Ali, J Almagro-Garcia… - Wellcome Open …, 2021 - ncbi.nlm.nih.gov
A major obstacle to malaria elimination is the great capacity of the parasite and vector
populations to evolve in response to malaria control interventions. The widespread use of …

[HTML][HTML] Major threat to malaria control programs by Plasmodium falciparum lacking histidine-rich protein 2, Eritrea

A Berhane, K Anderson, S Mihreteab… - Emerging infectious …, 2018 - ncbi.nlm.nih.gov
False-negative results for Plasmodium falciparum histidine-rich protein (HRP) 2–based
rapid diagnostic tests (RDTs) are increasing in Eritrea. We investigated HRP gene 2/3 …

[HTML][HTML] HRP2: transforming malaria diagnosis, but with caveats

KE Poti, DJ Sullivan, AM Dondorp, CJ Woodrow - Trends in parasitology, 2020 - cell.com
The major growth in point-of-care malaria diagnosis over the past decade has been based
on immunochromatographic malaria rapid diagnostic tests (mRDTs), which generally detect …

[PDF][PDF] Malaria rapid diagnostic test performance: results of WHO product testing of malaria RDTs: round 8 (2016–2018)

World Health Organization - 2018 - apps.who.int
WHO estimates that 3.2 billion people are at risk for malaria. In 2016, there were an
estimated 216 million new cases (with an uncertainty range of 196 million to 263 million) …

Pfhrp2-Deleted Plasmodium falciparum Parasites in the Democratic Republic of the Congo: A National Cross-sectional Survey

JB Parr, R Verity, SM Doctor, M Janko… - The Journal of …, 2017 - academic.oup.com
Abstract Background. Rapid diagnostic tests (RDTs) account for more than two-thirds of
malaria diagnoses in Africa. Deletions of the Plasmodium falciparum hrp2 (pfhrp2) gene …