Advances in the discovery of heterocyclic-based drugs against Alzheimer's disease

JD Sánchez, AR Alcántara, JF González… - Expert Opinion on …, 2023 - Taylor & Francis
Introduction Alzheimer's disease is a multifactorial neurodegenerative disorder
characterized by beta-amyloid accumulation and tau protein hyperphosphorylation. The …

Drug repurposing: small molecules against Cu (II)–amyloid-β and free radicals

G Nam, JM Suh, Y Yi, MH Lim - Journal of Inorganic Biochemistry, 2021 - Elsevier
Alzheimer's disease (AD) presents a complex pathology entangling numerous pathological
factors, including amyloid-β (Aβ), metal ions, and reactive oxygen species (ROS). Increasing …

Multitarget Diallyl Disulfides (DADS) against Aβ Aggregation: Screening through Molecular Docking with Aβ42 & ZnII‐Aβ16, ADME, DFT & Synthetic Strategy

S Singhal, P Khanna, N Misra, L Khanna - ChemistrySelect, 2021 - Wiley Online Library
The Aβ42 amyloid aggregation and its stabilization by coordination metals like ZnII through
chelation, are the major pathological causes behind the occurrence of Alzheimer's disease …

[HTML][HTML] Роль полиморфных генов матрикснных металлопротеиназ и ее тканевых ингибиторов при хроническом нефритическом синдроме у детей

Н Бозорова - Каталог диссертаций и авторефератов, 2023 - inlibrary.uz
Аннотация Актуальность и востребованность темы диссертации. На сегодняшний день
хронический нефритический синдром является одним из наиболее тяжелых …