Cardiac autonomic neuropathy in obesity, the metabolic syndrome and prediabetes: a narrative review

SM Williams, A Eleftheriadou, U Alam, DJ Cuthbertson… - Diabetes Therapy, 2019 - Springer
Cardiac autonomic neuropathy (CAN) is a major complication of type 1 and type 2 diabetes
mellitus (T1DM and T2DM). The increased morbidity, cardiovascular and all-cause mortality …

Heart failure with preserved ejection fraction: a comprehensive review and update of diagnosis, pathophysiology, treatment, and perioperative implications

PS Pagel, JN Tawil, BT Boettcher, DA Izquierdo… - Journal of cardiothoracic …, 2021 - Elsevier
Almost three-quarters of all heart failure patients who are older than 65 have heart failure
with preserved ejection fraction (HFpEF). The proportion and hospitalization rate of patients …

Neuroinflammation in heart failure: new insights for an old disease

HS Díaz, C Toledo, DC Andrade… - The Journal of …, 2020 - Wiley Online Library
Heart failure (HF) is a complex clinical syndrome affecting roughly 26 million people
worldwide. Increased sympathetic drive is a hallmark of HF and is associated with disease …

Cardiac vagal nerve activity increases during exercise to enhance coronary blood flow

J Shanks, M Pachen, JWH Chang, B George… - Circulation …, 2023 - Am Heart Assoc
BACKGROUND: The phrase complete vagal withdrawal is often used when discussing
autonomic control of the heart during exercise. However, more recent studies have …

Autonomic neuromodulation acutely ameliorates left ventricular strain in humans

N Tran, Z Asad, K Elkholey, BJ Scherlag, SS Po… - Journal of …, 2019 - Springer
Low-level transcutaneous vagus nerve stimulation at the tragus (LLTS) is anti-adrenergic.
We aimed to evaluate the acute effects of LLTS on left ventricular (LV) function and …

Predicting left ventricular contractile function via Gaussian process emulation in aortic-banded rats

S Longobardi, A Lewalle… - … of the Royal …, 2020 - royalsocietypublishing.org
Cardiac contraction is the result of integrated cellular, tissue and organ function. Biophysical
in silico cardiac models offer a systematic approach for studying these multi-scale …

Neurocognitive disorders in heart failure: novel pathophysiological mechanisms underpinning memory loss and learning impairment

C Toledo, DC Andrade, HS Díaz, NC Inestrosa… - Molecular …, 2019 - Springer
Heart failure (HF) is a major public health issue affecting more than 26 million people
worldwide. HF is the most common cardiovascular disease in elder population; and it is …

Central and peripheral chemoreflexes in humans with treated hypertension

ALC Sayegh, JL Fan, M Dawes… - The Journal of …, 2023 - Wiley Online Library
Increased peripheral chemoreflex sensitivity is a pathogenic feature of human hypertension
(HTN), while both central and peripheral chemoreflex sensitivities are reportedly augmented …

Cardiac remodeling and arrhythmogenesis are ameliorated by administration of Cx43 mimetic peptide Gap27 in heart failure rats

CM Lucero, DC Andrade, C Toledo, HS Díaz… - Scientific Reports, 2020 - nature.com
Alterations in connexins and specifically in 43 isoform (Cx43) in the heart have been
associated with a high incidence of arrhythmogenesis and sudden death in several cardiac …

Cardiorespiratory alterations following intermittent photostimulation of RVLM C1 neurons: implications for long‐term blood pressure, breathing and sleep regulation in …

C Toledo, DC Andrade, E Diaz‐Jara… - Acta …, 2022 - Wiley Online Library
Aim Sympathoexcitation and sleep‐disordered breathing are common contributors for
disease progression. Catecholaminergic neurons from the rostral ventrolateral medulla …