Refractive index measurement of pharmaceutical solids: a review of measurement methods and pharmaceutical applications

S Mohan, E Kato, JK Drennen III… - Journal of Pharmaceutical …, 2019 - Elsevier
Refractive index is an important optical parameter that can be used to characterize the
physicochemical properties of pharmaceutical solids. The complexity of most drugs and …

Efficiency of near-infrared spectroscopy in classifying Amazonian wood wastes for bioenergy generation

MDR Lima, PF Trugilho, L Bufalino, AFD Júnior… - Biomass and …, 2022 - Elsevier
Finding methods to classify heterogeneous logging wastes from sustainable forest
management in the Brazilian Amazonia is essential to increase the production and quality of …

Application of a wavelength angle mapper for variable selection in iterative optimization technology predictions of drug content in pharmaceutical powder mixtures

AJ Rish, SR Henson, NL Velez-Silva, MN Hasan… - International Journal of …, 2023 - Elsevier
Process analytical technology (PAT) is an essential tool within pharmaceutical
manufacturing to ensure consistent quality and maintain process control. Near-infrared (NIR) …

Continuous manufacturing of pharmaceutical products: A density-insensitive near infrared method for the in-line monitoring of continuous powder streams

NL Velez-Silva, JK Drennen III, CA Anderson - International Journal of …, 2024 - Elsevier
Near infrared (NIR) spectroscopy is a valuable analytical technique for monitoring chemical
composition of powder blends in continuous pharmaceutical processes. However, the …

Capacitance spectroscopy enables real‐time monitoring of early cell death in mammalian cell culture

S Wu, SA Ketcham, CC Corredor, D Both… - Biotechnology …, 2023 - Wiley Online Library
Abstract Background/Aims Previous work developed a quantitative model using capacitance
spectroscopy in an at‐line setup to predict the dying cell percentage measured from a flow …

Unveiling non-linear water effects in near infrared spectroscopy: A study on organic wastes during drying using chemometrics

A Mallet, C Charnier, É Latrille, R Bendoula… - Waste Management, 2021 - Elsevier
In the context of organic waste management, near infrared spectroscopy (NIRS) is being
used to offer a fast, non-destructive, and cost-effective characterization system. However …

Development of an in-line near-infrared method for blend content uniformity assessment in a tablet feed frame

Y Li, CA Anderson, JK Drennen III… - Applied …, 2019 - journals.sagepub.com
Process analytical technology (PAT) has shown great potential for in-line tableting process
monitoring. The study focuses on the development and validation of an in-line near-infrared …

Estimation of the deoxynivalenol and moisture contents of bulk wheat grain samples by FT‐NIR spectroscopy

KHS Peiris, Y Dong, MA Davis, WW Bockus… - Cereal …, 2017 - Wiley Online Library
Deoxynivalenol (DON) levels in harvested grain samples are used to evaluate the Fusarium
head blight (FHB) resistance of wheat cultivars and breeding lines. Fourier transform near …

Development of calibration-free/minimal calibration wavelength selection for iterative optimization technology algorithms toward process analytical technology …

AJ Rish, SR Henson, MA Alam, Y Liu… - International journal of …, 2022 - Elsevier
As continuous manufacturing (CM) processes are developed, process analytical technology
(PAT) via NIR spectroscopy has become an integral tool in process monitoring. NIR …

Designing a calibration set in spectral space for efficient development of an NIR method for tablet analysis

MA Alam, J Drennen III, C Anderson - Journal of pharmaceutical and …, 2017 - Elsevier
Designing a calibration set is the first step in developing a multivariate spectroscopic
calibration method for quantitative analysis of pharmaceutical tablets. This step is critical …