The tumor necrosis factor (TNF)-α-induced protein 8 (TNFAIP8/TIPE) family is a death
effector domain (DED)-containing protein family with four identified members: TNFAIP8 …

Abstract Since the mid-1950's, melanoma incidence has been rising steadily in
industrialized Caucasian populations, thereby pointing to the pivotal involvement of …

Pancreatic cancer is one of the deadliest human malignancies and little progress has been
achieved in its treatment over the past decades. Advances in our understanding of the …

The Ras superfamily of small GTPases is a group of more than 150 small G proteins, all of
which share some degree of homology to the founding member Ras. These small GTPases …

The maturation process of NK cells determines their functionality during which IL-15 plays a
critical role. However, very few checkpoints specifically targeting this process have been …

More than half of human cancers have aberrantly upregulated phosphoinositide signals; yet
how phospholipid signals are controlled during tumorigenesis is not fully understood. We …

The TIPE (tumor necrosis factor-α-induced protein 8-like) family are newly described
regulators of immunity and tumorigenesis consisting of four highly homologous mammalian …

Tumor necrosis factor (TNF)-α-induced protein 8 (TNFAIP8) is a founding member of the
TIPE family, which also includes TNFAIP8-like 1 (TIPE1), TNFAIP8-like 2 (TIPE2), and …

Phagocytosis and oxidative burst are two major effector arms of innate immunity. Although it
is known that both are activated by Toll-like receptors (TLRs) and Rac GTPases, how their …

Myeloid-derived suppressor cells (MDSCs) are “polarized” myeloid cells that effectively
promote tumorigenesis by inhibiting antitumor immunity. How myeloid cells acquire the …