Transient physical association between enzymes appears to be a cardinal feature of
metabolic systems, yet the purpose of this metabolic organisation remains enigmatic. It is …

Covering: up to mid of 2018 Type I fatty acid synthases (FASs) are giant multienzymes
catalyzing all steps of the biosynthesis of fatty acids from acetyl-and malonyl-CoA by iterative …

Fatty acids are primary metabolites synthesized by complex, elegant, and essential
biosynthetic machinery. Fatty acid synthases resemble an iterative assembly line, with an …

Medium-chain fatty acids (MCFAs; C6–C12) are valuable molecules used for biofuel and
oleochemical production; however, it is challenging to synthesize these fatty acids efficiently …

Fatty acids (FAs) are considered strategically important platform compounds that can be
accessed by sustainable microbial approaches. Here we report the reprogramming of chain …

Three decades of studies on the multifunctional 6-deoxyerythronolide B synthase have laid
a foundation for understanding the chemistry and evolution of polyketide antibiotic …

Covering: mid 1990s to 2018 Over the last two decades, diverse approaches have been
explored to generate new polyketides by engineering polyketide synthases (PKSs) …

Fatty acids are crucial molecules for most living beings, very well spread and conserved
across species. These molecules play a role in energy storage, cell membrane architecture …

De novo biosynthesis of fatty acids is an iterative process requiring strict regulation of the
lengths of the produced fatty acids. In this review, we focus on the factors determining chain …

Megasynthases, such as type I fatty acid and polyketide synthases (FASs and PKSs), are
multienzyme complexes responsible for producing primary metabolites and complex natural …