Therapy of leptomeningeal metastasis in solid tumors

F Mack, BG Baumert, N Schäfer, E Hattingen… - Cancer treatment …, 2016 - Elsevier
Leptomeningeal metastasis (LM), ie the seeding of tumor cells to the cerebrospinal fluid
(CSF) and the leptomeninges, is a devastating and mostly late-stage complication of various …

Leptomeningeal spread in glioblastoma: diagnostic and therapeutic challenges

C Birzu, S Tran, F Bielle, M Touat, K Mokhtari… - The …, 2020 - academic.oup.com
Background Glioblastoma (GBM) is the most common and aggressive primary malignant
brain tumor. Leptomeningeal spread (LMS) is a severe complication of GBM, raising …

Classification of progression patterns in glioblastoma: analysis of predictive factors and clinical implications

H Jiang, K Yu, M Li, Y Cui, X Ren, C Yang… - Frontiers in …, 2020 - frontiersin.org
Background This study was designed to explore the progression patterns of IDH-wildtype
glioblastoma (GBM) at first recurrence after chemoradiotherapy. Methods Records from 247 …

Human cerebrospinal fluid affects chemoradiotherapy sensitivities in tumor cells from patients with glioblastoma

BW Stringer, MI De Silva, Z Greenberg… - Science …, 2023 - science.org
Cancers in the central nervous system resist therapies effective in other cancers, possibly
due to the unique biochemistry of the human brain microenvironment composed of …

Leptomeningeal metastases in glioma: the memorial sloan kettering cancer center experience

BM Andersen, C Miranda, V Hatzoglou, LM DeAngelis… - Neurology, 2019 - AAN Enterprises
Objective To perform a retrospective analysis examining the incidence and prognosis of
glioma patients with leptomeningeal disease (LMD) at Memorial Sloan Kettering Cancer …

Radiomics-based neural network predicts recurrence patterns in glioblastoma using dynamic susceptibility contrast-enhanced MRI

KY Shim, SW Chung, JH Jeong, I Hwang, CK Park… - Scientific reports, 2021 - nature.com
Glioblastoma remains the most devastating brain tumor despite optimal treatment, because
of the high rate of recurrence. Distant recurrence has distinct genomic alterations compared …

Radiotherapy in leptomeningeal disease: a systematic review of randomized and non-randomized trials

SM Buszek, C Chung - Frontiers in oncology, 2019 - frontiersin.org
Background: Leptomeningeal disease (LMD), also known as neoplastic meningitis,
leptomeningeal carcinomatosis, or carcinomatous meningitis, is a rare cancer complication …

Leptomeningeal disease in glioblastoma: endgame or opportunity?

S Akmal, EE Ginalis, NV Patel, R Aiken… - Journal of Neuro …, 2021 - Springer
Introduction Glioblastoma is an aggressive cancer with a notoriously poor prognosis. Recent
advances in treatment have increased overall survival, though this may be accompanied by …

Leptomeningeal metastases in glioma revisited: incidence and molecular predictors based on postcontrast fluid-attenuated inversion recovery imaging

YW Park, K Han, JE Park, SS Ahn, EH Kim, J Kim… - Journal of …, 2022 - thejns.org
OBJECTIVE Leptomeningeal metastases (LMs) in glioma have been underestimated given
their low incidence and the lack of reliable imaging. Authors of this study aimed to …

Natural history of spinal cord metastasis from brain glioblastomas

A Amelot, LM Terrier, G Cognacq, V Jecko… - Journal of neuro …, 2023 - Springer
Abstract Background and Objectives Spinal cord metastasis arising from an intracranial
glioblastoma is a rare and late event during the natural course of the disease. These …