Synthetic glycans to improve current glycoconjugate vaccines and fight antimicrobial resistance

L Del Bino, KE Østerlid, DY Wu, F Nonne… - Chemical …, 2022 - ACS Publications
Antimicrobial resistance (AMR) is emerging as the next potential pandemic. Different
microorganisms, including the bacteria Acinetobacter baumannii, Clostridioides difficile …

Protein post-translational modifications in bacteria

B Macek, K Forchhammer, J Hardouin… - Nature Reviews …, 2019 - nature.com
Over the past decade the number and variety of protein post-translational modifications that
have been detected and characterized in bacteria have rapidly increased. Most post …

[HTML][HTML] N-linked protein glycosylation in the ER

M Aebi - Biochimica et Biophysica Acta (BBA)-Molecular Cell …, 2013 - Elsevier
N-linked protein glycosylation in the endoplasmic reticulum (ER) is a conserved two phase
process in eukaryotic cells. It involves the assembly of an oligosaccharide on a lipid carrier …

Chemoenzymatic methods for the synthesis of glycoproteins

C Li, LX Wang - Chemical reviews, 2018 - ACS Publications
Glycosylation is one of the most prevalent posttranslational modifications that profoundly
affects the structure and functions of proteins in a wide variety of biological recognition …

Mechanisms and principles of N-linked protein glycosylation

F Schwarz, M Aebi - Current opinion in structural biology, 2011 - Elsevier
N-linked glycosylation, a protein modification system present in all domains of life, is
characterized by a high structural diversity of N-linked glycans found among different …

Industrial production of recombinant therapeutics in Escherichia coli and its recent advancements

CJ Huang, H Lin, X Yang - Journal of Industrial Microbiology and …, 2012 - academic.oup.com
Nearly 30% of currently approved recombinant therapeutic proteins are produced in
Escherichia coli. Due to its well-characterized genetics, rapid growth and high-yield …

On-demand biomanufacturing of protective conjugate vaccines

JC Stark, T Jaroentomeechai, TD Moeller… - Science …, 2021 - science.org
Conjugate vaccines are among the most effective methods for preventing bacterial
infections. However, existing manufacturing approaches limit access to conjugate vaccines …

Protein glycosylation in bacteria: sweeter than ever

H Nothaft, CM Szymanski - Nature Reviews Microbiology, 2010 - nature.com
Investigations into bacterial protein glycosylation continue to progress rapidly. It is now
established that bacteria possess both N-linked and O-linked glycosylation pathways that …

Cell‐free protein synthesis: pros and cons of prokaryotic and eukaryotic systems

A Zemella, L Thoring, C Hoffmeister, S Kubick - ChemBioChem, 2015 - Wiley Online Library
From its start as a small‐scale in vitro system to study fundamental translation processes,
cell‐free protein synthesis quickly rose to become a potent platform for the high‐yield …

Campylobacter jejuni: molecular biology and pathogenesis

KT Young, LM Davis, VJ DiRita - Nature Reviews Microbiology, 2007 - nature.com
Campylobacter jejuni is a foodborne bacterial pathogen that is common in the developed
world. However, we know less about its biology and pathogenicity than we do about other …