The neurobiology of irritable bowel syndrome

EA Mayer, HJ Ryu, RR Bhatt - Molecular psychiatry, 2023 - nature.com
Irritable bowel syndrome (IBS) is the most prevalent disorder of brain-gut interactions that
affects between 5 and 10% of the general population worldwide. The current symptom …

Systematic review with meta‐analysis: the prevalence of anxiety and depression in patients with irritable bowel syndrome

M Zamani, S Alizadeh‐Tabari… - Alimentary pharmacology …, 2019 - Wiley Online Library
Background Irritable bowel syndrome (IBS) is a common and potential disabling functional
gastrointestinal disorder. Studies have revealed a possible association between IBS and …

The gut microbiome from patients with schizophrenia modulates the glutamate-glutamine-GABA cycle and schizophrenia-relevant behaviors in mice

P Zheng, B Zeng, M Liu, J Chen, J Pan, Y Han… - Science …, 2019 - science.org
Schizophrenia (SCZ) is a devastating mental disorder with poorly defined underlying
molecular mechanisms. The gut microbiome can modulate brain function and behaviors …

Central regulation of stress-evoked peripheral immune responses

KL Chan, WC Poller, FK Swirski… - Nature Reviews …, 2023 - nature.com
Stress-linked psychiatric disorders, including anxiety and major depressive disorder, are
associated with systemic inflammation. Recent studies have reported stress-induced …

Associations of neurotransmitters and the gut microbiome with emotional distress in mixed type of irritable bowel syndrome

ZA Barandouzi, J Lee, M del Carmen Rosas, J Chen… - Scientific Reports, 2022 - nature.com
Evidence highlights the comorbidity between emotional distress and irritable bowel
syndrome (IBS) through the gut-brain axis. However, the underlying mechanism is largely …

Microbiome-gut-brain axis and toll-like receptors in Parkinson's disease

V Caputi, MC Giron - International journal of molecular sciences, 2018 - mdpi.com
Parkinson's disease (PD) is a progressively debilitating neurodegenerative disease
characterized by α-synucleinopathy, which involves all districts of the brain-gut axis …

Irritable bowel syndrome and the gut microbiome: a comprehensive review

SD Shaikh, N Sun, A Canakis, WY Park… - Journal of Clinical …, 2023 - mdpi.com
Irritable Bowel Syndrome (IBS) is a functional disorder of the gastrointestinal tract
characterized by abdominal pain and altered bowel habits. It has a prevalence of 10 to 25 …

Feeling down? A systematic review of the gut microbiota in anxiety/depression and irritable bowel syndrome

CA Simpson, A Mu, N Haslam, OS Schwartz… - Journal of affective …, 2020 - Elsevier
Background Anxiety/depression and irritable bowel syndrome (IBS) are highly prevalent and
burdensome conditions, whose co-occurrence is estimated between 44 and 84%. Shared …

Antidepressants, antimicrobials or both? Gut microbiota dysbiosis in depression and possible implications of the antimicrobial effects of antidepressant drugs for …

D Macedo, AJM Chaves Filho, CNS de Sousa… - Journal of affective …, 2017 - Elsevier
Objectives The first drug repurposed for the treatment of depression was the tuberculostatic
iproniazid. At present, drugs belonging to new classes of antidepressants still have …

One health, fermented foods, and gut microbiota

V Bell, J Ferrão, L Pimentel, M Pintado, T Fernandes - Foods, 2018 - mdpi.com
Changes in present-day society such as diets with more sugar, salt, and saturated fat, bad
habits and unhealthy lifestyles contribute to the likelihood of the involvement of the …