The conjugation of biomolecules can impart materials with the bioactivity necessary to
modulate specific cell behaviors. While the biological roles of particular polypeptide …

Simple Summary Chemotherapy is a key modality in today's practice of clinical oncology.
The potential for systemic treatment of cancer patients with cytotoxic agents was discovered …

Protein conjugates are valuable tools for studying biological processes or producing
therapeutics, such as antibody–drug conjugates. Despite the development of several protein …

Site‐selective protein functionalization serves as an invaluable tool for investigating protein
structures and functions in complicated cellular environments and accomplishing semi …

Peptide and protein selective modification at tyrosine residues has become an exploding
field of research as tyrosine constitutes a robust alternative to lysine and cysteine-targeted …

Protein bioconjugation is an increasingly important field of research, with wide-ranging
applications in areas such as therapeutics and biomaterials. Traditional cysteine and lysine …

A strategy for the preparation of homogeneous antibody–drug conjugates (ADCs) containing
multiple payloads has been developed. This approach utilizes sequential unmasking of …

Antibody–drug conjugates (ADCs) are emerging therapeutic agents in the treatment of
cancer, and various conjugation strategies and chemical linkers have been developed to …

Due to their exquisite cysteine-selectivity, excellent stability, and ability to functionally
rebridge disulfide bonds, dibromopyridazinediones are emerging as an exciting new class …

Widely used reagents in the peptide functionalization toolbox, Michael acceptors and N‐
hydroxysuccinimide (NHS) activated esters, are combined in NHS‐activated acrylamides for …