Hypoxia-induced alternative splicing is a potent driving force in tumour pathogenesis and
progression. In this review, we update currents concepts of hypoxia-induced alternative …

Renal cell carcinoma (RCC) is a highly vascularized tumor and prone to distant metastasis.
Sorafenib is the first targeted multikinase inhibitor and first-line chemical drug approved for …

The P2X7 receptor, an ATP‐gated ion channel, is critical for cancer cell growth,
invasiveness, and angiogenesis. Previous studies indicate that P2X7 regulates osteoblast …

Lung adenocarcinoma is the most common form of lung cancer, accounting for 60% of non-
small cell lung cancer (NSCLC) cases in Asian patients. Importantly, nearly half of these …

Atherosclerosis is a chronic inflammatory disease with high morbidity and mortality rates
worldwide. Doublecortin‐like kinase 1 (DCLK1), a microtubule‐associated protein kinase, is …

Immunotherapy that has proven efficacy in several solid cancers plays a partial role in
improving clinical outcomes of advanced gastrointestinal (GI) cancers. There is an unmet …

Abstract Rationale: Doublecortin-like kinase 1 (DCLK1) is a serine/threonine kinase that
selectively marks cancer stem-like cells (CSCs) and promotes malignant progression in …

Doublecortin-like kinase 1 (DCLK1), a protein molecule, has been identified as a tumor stem
cell marker in the cancer cells of gastrointestinal, pancreas, and human colon. DCLK1 …

Abstract Background To date, 5‐fluorouracil‐based chemotherapy is very important for
locally advanced or metastatic colorectal cancer (CRC). However, chemotherapy resistance …

Simple Summary Doublecortin-like kinase 1 (DCLK1) is a tumor stem cell marker in colon,
pancreatic, and potentially other cancers that has received wide attention recently. Aside …