Assessment of Ki67 in breast cancer: updated recommendations from the international Ki67 in breast cancer working group

TO Nielsen, SCY Leung, DL Rimm… - JNCI: Journal of the …, 2021 - academic.oup.com
Abstract Ki67 immunohistochemistry (IHC), commonly used as a proliferation marker in
breast cancer, has limited value for treatment decisions due to questionable analytical …

Artificial intelligence as the next step towards precision pathology

B Acs, M Rantalainen, J Hartman - Journal of internal medicine, 2020 - Wiley Online Library
Pathology is the cornerstone of cancer care. The need for accuracy in histopathologic
diagnosis of cancer is increasing as personalized cancer therapy requires accurate …

Estrogen and progesterone receptor testing in breast cancer: ASCO/CAP guideline update

KH Allison, MEH Hammond, M Dowsett… - Journal of Clinical …, 2020 - ascopubs.org
PURPOSE To update key recommendations of the American Society of Clinical
Oncology/College of American Pathologists estrogen (ER) and progesterone receptor (PgR) …

[HTML][HTML] The explainability paradox: Challenges for xAI in digital pathology

T Evans, CO Retzlaff, C Geißler, M Kargl… - Future Generation …, 2022 - Elsevier
The increasing prevalence of digitised workflows in diagnostic pathology opens the door to
life-saving applications of artificial intelligence (AI). Explainability is identified as a critical …

Estrogen and progesterone receptor testing in breast cancer: American Society of Clinical Oncology/College of American Pathologists guideline update

KH Allison, MEH Hammond… - … of pathology & …, 2020 - meridian.allenpress.com
Purpose.—To update key recommendations of the American Society of Clinical
Oncology/College of American Pathologists estrogen receptor (ER) and progesterone …

Endocrine therapy response and 21-gene expression assay for therapy guidance in HR+/HER2–early breast cancer

UA Nitz, O Gluz, S Kümmel, M Christgen… - Journal of Clinical …, 2022 - ascopubs.org
PURPOSE To our knowledge, WSG-ADAPT-HR+/HER2–(ClinicalTrials. gov identifier:
NCT01779206; n= 5,625 registered) is the first trial combining the 21-gene expression …

Artificial intelligence applied to breast pathology

M Yousif, PJ van Diest, A Laurinavicius, D Rimm… - Virchows Archiv, 2022 - Springer
The convergence of digital pathology and computer vision is increasingly enabling
computers to perform tasks performed by humans. As a result, artificial intelligence (AI) is …

Systematically higher Ki67 scores on core biopsy samples compared to corresponding resection specimen in breast cancer: a multi-operator and multi-institutional …

B Acs, SCY Leung, KM Kidwell, I Arun, R Augulis… - Modern …, 2022 - nature.com
Ki67 has potential clinical importance in breast cancer but has yet to see broad acceptance
due to inter-laboratory variability. Here we tested an open source and calibrated automated …

The evolution of Ki-67 and breast carcinoma: past observations, present directions, and future considerations

BS Finkelman, H Zhang, DG Hicks, BM Turner - Cancers, 2023 - mdpi.com
Simple Summary Cellular proliferation is a central determinant of breast cancer recurrence
risk and response to chemotherapy. The discovery of the Ki-67 antibody by Dr. Johannes …

The use of digital pathology and image analysis in clinical trials

R Pell, K Oien, M Robinson, H Pitman… - The Journal of …, 2019 - Wiley Online Library
Digital pathology and image analysis potentially provide greater accuracy, reproducibility
and standardisation of pathology‐based trial entry criteria and endpoints, alongside …