The extracellular matrix (ECM) plays a key role as both structural scaffold and regulator of
cell signal transduction in tissues. In times of ECM assembly and turnover, cells upregulate …

Nanoparticle (NP)-based therapeutics have ushered in a new era in translational medicine.
However, despite the clinical success of NP technology, it is not well-understood how NPs …

Soft connective tissues at steady state are dynamic; resident cells continually read
environmental cues and respond to them to promote homeostasis, including maintenance of …

Simple Summary For the research and development of drug discovery, it is of prime
importance to construct the three-dimensional (3D) tissue models in vitro. To this end, the …

Fibronectin is an extracellular matrix protein that is present during periods of change within
tissues. It is upregulated and necessary in a number of developmental contexts, and it is …

It has been recognized that cancer is not merely a disease of tumor cells, but a disease of
imbalance, in which stromal cells and tumor microenvironment play crucial roles …

Background: Fibronectin (FN) polymerization is necessary for collagen matrix deposition
and is a key contributor to increased abundance of cardiac myofibroblasts (MFs) after …

The composition of a bone can be described in terms of the mineral phase, hydroxyapatite,
the organic phase, which consists of collagen type I, noncollagenous proteins, other …

Thoracic aortic diseases that involve progressive enlargement, acute dissection, or rupture
are influenced by the hemodynamic loads and mechanical properties of the wall. We have …

The extracellular matrix (ECM) is a key regulator of cell and tissue function. Traditionally, the
ECM has been thought of primarily as a physical scaffold that binds cells and tissues …