Regulatory B cells (Bregs) is a term that encompasses all B cells that act to suppress
immune responses. Bregs contribute to the maintenance of tolerance, limiting ongoing …

The primary immunodeficiency diseases (PIDs) include many genetic disorders that affect
different components of the innate and adaptive responses. The number of distinct genetic …

Abstract The Wiskott-Aldrich syndrome (WAS) is a rare X-linked disorder originally described
by Dr. Alfred Wiskott in 1937 and Dr. Robert Aldrich in 1954 as a familial disease …

The interest in regulatory B cells (Bregs) began in the 1970s with the evidence that B cells
could downregulate the immune system by the production of “inhibitory” antibodies …

Abstract The Wiskott–Aldrich syndrome protein (WASP) participates in innate and adaptive
immunity through regulation of actin cytoskeleton‐dependent cellular processes, including …

Wiskott-Aldrich syndrome (WAS) is a rare X-linked disorder characterized by combined
immunodeficiency, eczema, microthrombocytopenia, autoimmunity, and lymphoid …

Dysregulation of autophagy and inflammasome activity contributes to the development of
auto-inflammatory diseases. Emerging evidence highlights the importance of the actin …

Wiskott–Aldrich syndrome (WAS) is an uncommon X-linked combined-immunodeficiency
disorder characterized by a triad of thrombocytopenia, eczema, and immunodeficiency …

The treatment of primary immunodeficiency disorders with allogeneic hematopoietic cell
transplantation (HCT) has a history dating back to 1968 with the first successful transplant for …

Regulatory T cells (Tregs) play a crucial role in enforcing immune tolerance in the periphery,
preventing the activation of autoreactive cells, production of autoantibodies, and …