Background eIF2α is a regulatory node that controls protein synthesis initiation by its
phosphorylation or dephosphorylation. General control nonderepressible-2 (GCN2), protein …

The respiratory tract and its resident immune cells face daily exposure to stress, both from
without and from within. Inhaled pathogens, including severe acute respiratory syndrome …

The integrated stress response (ISR) is an essential stress-support pathway increasingly
recognized as a determinant of tumorigenesis. Here we demonstrate that ISR is pivotal in …

Protein homeostasis is modulated by stress response pathways and its deficiency is a
hallmark of aging. The integrated stress response (ISR) is a conserved stress-signaling …

Epigenetic regulation of gene transcription has been shown to coordinate with nutrient
availability, yet the mechanisms underlying this coordination remain incompletely …

Asparagine, an important amino acid in mammals, is produced in several organs and is
widely used for the production of other nutrients such as glucose, proteins, lipids, and …

Multiple molecular features, such as activation of specific oncogenes (eg, MYC, BCL2) or a
variety of gene expression signatures, have been associated with disease course in diffuse …

Cancer cells adapt multiple mechanisms to counter intense stress on their way to growth.
Tumor microenvironment stress leads to canonical and noncanonical endoplasmic stress …

Non-small cell lung cancer (NSCLC) represents the most common histological type of lung
cancer, characterized by a five-year survival rate of 15% and poor prognosis. Accumulating …

Objective Cancer cells undergo adaptive processes that favor their survival and proliferation
when subjected to different types of cellular stress. These changes are linked to oncogenic …