The aldo-keto reductases (AKRs): Overview
TM Penning - Chemico-biological interactions, 2015 - Elsevier
The aldo-keto reductase (AKR) protein superfamily contains> 190 members that fall into 16
families and are found in all phyla. These enzymes reduce carbonyl substrates such as …
families and are found in all phyla. These enzymes reduce carbonyl substrates such as …
Steroid hormones and their action in women's brains: the importance of hormonal balance
Sex hormones significantly impact women's lives. Throughout the different stages of life,
from menarche to menopause and all stages in between, women experience dramatic …
from menarche to menopause and all stages in between, women experience dramatic …
A positive feedback loop of AKR1C3-mediated activation of NF-κB and STAT3 facilitates proliferation and metastasis in hepatocellular carcinoma
Q Zhou, W Tian, Z Jiang, T Huang, C Ge, T Liu, F Zhao… - Cancer Research, 2021 - AACR
AKR1C3 is an enzyme belonging to the aldo-ketoreductase family, the members of which
catalyze redox transformations involved in biosynthesis, intermediary metabolism, and …
catalyze redox transformations involved in biosynthesis, intermediary metabolism, and …
AKR1C3 (type 5 17β-hydroxysteroid dehydrogenase/prostaglandin F synthase): Roles in malignancy and endocrine disorders
TM Penning - Molecular and cellular endocrinology, 2019 - Elsevier
Abstract Aldo-Keto-Reductase 1C3 (type 5 17β-hydroxysteroid dehydrogenase
(HSD)/prostaglandin (PG) F 2α synthase) is the only 17β-HSD that is not a short-chain …
(HSD)/prostaglandin (PG) F 2α synthase) is the only 17β-HSD that is not a short-chain …
Progress in progestin-based therapies for neurological disorders
R Sitruk-Ware, B Bonsack, R Brinton… - Neuroscience & …, 2021 - Elsevier
Hormone therapy, primarily progesterone and progestins, for central nervous system (CNS)
disorders represents an emerging field of regenerative medicine. Following a failed clinical …
disorders represents an emerging field of regenerative medicine. Following a failed clinical …
Potent and Highly Selective Aldo–Keto Reductase 1C3 (AKR1C3) Inhibitors Act as Chemotherapeutic Potentiators in Acute Myeloid Leukemia and T-Cell Acute …
Aldo–keto reductase 1C3 (AKR1C3) catalyzes the synthesis of 9α, 11β-prostaglandin (PG)
F2α and PGF2α prostanoids that sustain the growth of myeloid precursors in the bone …
F2α and PGF2α prostanoids that sustain the growth of myeloid precursors in the bone …
[HTML][HTML] Aldo-keto reductase 1C3—Assessment as a new target for the treatment of endometriosis
TL Rižner, TM Penning - Pharmacological research, 2020 - Elsevier
Endometriosis is a common gynecological disorder, which is treated surgically and/or
pharmacologically with an unmet clinical need for new therapeutics. A completed phase I …
pharmacologically with an unmet clinical need for new therapeutics. A completed phase I …
Human AKR1C3 binds agonists of GPR84 and participates in an expanded polyamine pathway
Altered human aldo-keto reductase family 1 member C3 (AKR1C3) expression has been
associated with poor prognosis in diverse cancers, ferroptosis resistance, and metabolic …
associated with poor prognosis in diverse cancers, ferroptosis resistance, and metabolic …
Modulation of cell metabolic pathways and oxidative stress signaling contribute to acquired melphalan resistance in multiple myeloma cells
Alkylating agents are widely used chemotherapeutics in the treatment of many cancers,
including leukemia, lymphoma, multiple myeloma, sarcoma, lung, breast and ovarian …
including leukemia, lymphoma, multiple myeloma, sarcoma, lung, breast and ovarian …
The other side of progestins: effects in the brain
S Giatti, RC Melcangi… - Journal of Molecular …, 2016 - jme.bioscientifica.com
Progestins are a broad class of progestational agents widely differing in their chemical
structures and pharmacological properties. Despite emerging data suggest that progestins …
structures and pharmacological properties. Despite emerging data suggest that progestins …