Ischemic stroke is a leading cause of morbidity and death, with the outcome largely
determined by the amount of hypoxia-related neuronal death in the affected brain regions …

Ischemic stroke (IS) is characterized by high incidence, high recurrence, and high mortality
and places a heavy burden on society and families. The pathological mechanisms of IS are …

The mechanisms underlying the neuroprotective effects of hesperidin in a murine model of
PD are not fully elucidated. The current study was carried out to investigate the ability of …

Background Two recently developed novel rodent models have been reported to ablate
microglia, either by genetically targeting microglia (via Cx3cr1-creER: iDTR+ Dtx) or through …

Disruptions in brain energy metabolism, oxidative damage, and neuroinflammation are
commonly seen in traumatic brain injury (TBI). Microglial activation is the hallmark of …

Traumatic brain injury (TBI) is one of the most common causes of death and disability
worldwide. We investigated whether inhibition of p53 using pifithrin (PFT)-α or PFT-μ …

Stroke is one of the most threatening diseases worldwide, particularly in countries with
larger populations; it is associated with high morbidity, mortality and disability rates. As a …

Background/Aims: This study focused on evaluating the effect of MALAT1 and MDM2 on
ischemic stroke through regulation of the p53 signaling pathway. Materials: Bioinformatics …

For more than three decades, numerous studies have demonstrated the function of p53 in
cell cycle, cellular senescence, autophagy, apoptosis, and metabolism. Among diverse …

Background After ischemic stroke (IS), peripheral leukocytes infiltrate the damaged region
and modulate the response to injury. Peripheral blood cells display distinctive gene …