Cell death in photodynamic therapy: From oxidative stress to anti-tumor immunity

C Donohoe, MO Senge, LG Arnaut… - … et Biophysica Acta (BBA …, 2019 - Elsevier
Photodynamic therapy is a promising approach for cancer treatment that relies on the
administration of a photosensitizer followed by tumor illumination. The generated oxidative …

Singlet oxygen, photodynamic therapy, and mechanisms of cancer cell death

PS Maharjan, HK Bhattarai - Journal of oncology, 2022 - Wiley Online Library
Photodynamic therapy (PDT) can be developed into an important arsenal against cancer; it
is a minimally invasive therapy, which is used in the treatment or/and palliation of a variety of …

Understanding membrane remodelling initiated by photosensitized lipid oxidation

TM Tsubone, MS Baptista, R Itri - Biophysical chemistry, 2019 - Elsevier
In this review, we describe how photooxidation changes membrane properties that can
ultimately lead to permanent membrane damage. Lipid photooxidation occurs in the …

A Systematic Evaluation of Curcumin Concentrations and Blue Light Parameters towards Antimicrobial Photodynamic Therapy against Cariogenic Microorganisms

P Comeau, A Manso - Pharmaceutics, 2023 - mdpi.com
Dental caries is a highly preventable and costly disease. Unfortunately, the current
management strategies are inadequate at reducing the incidence and new minimally …

[HTML][HTML] Attritional evaluation of lipophilic and hydrophilic metallated phthalocyanines for oncological photodynamic therapy

LM Dias, F Sharifi, MJ de Keijzer, B Mesquita… - … of Photochemistry and …, 2021 - Elsevier
Background and aim Oncological photodynamic therapy (PDT) relies on photosensitizers
(PSs) to photo-oxidatively destroy tumor cells. Currently approved PSs yield satisfactory …

The potential of nanobody-targeted photodynamic therapy to trigger immune responses

I Beltrán Hernández, ML Angelier… - Cancers, 2020 - mdpi.com
Nanobody-targeted photodynamic therapy (NB-PDT) has been recently developed as a
more tumor-selective approach rather than conventional photodynamic therapy (PDT). NB …

Chimeric peptide nanorods for plasma membrane and nuclear targeted photosensitizer delivery and enhanced photodynamic therapy

H Cheng, P Yuan, G Fan, L Zhao, R Zheng… - Applied Materials …, 2019 - Elsevier
Tumor therapeutic efficiency is largely determined by the delivery efficacy of therapeutic
agent to its final target, especially for photodynamic therapy (PDT). Although plasma …

Hypericin–Apomyoglobin: An Enhanced Photosensitizer Complex for the Treatment of Tumor Cells

P Bianchini, M Cozzolino, M Oneto, L Pesce… - …, 2019 - ACS Publications
Bioavailability of photosensitizers for cancer photodynamic therapy is often hampered by
their low solubility in water. Here, we overcome this issue by using the water-soluble protein …

Photodynamic priming modulates cellular ATP levels to overcome P‐glycoprotein‐mediated drug efflux in chemoresistant triple‐negative breast cancer

I Rahman, B Liang, A Sajid… - Photochemistry and …, 2024 - Wiley Online Library
Abstract P‐glycoprotein (P‐gp, ABCB1) is a well‐researched ATP‐binding cassette (ABC)
drug efflux transporter linked to the development of cancer multidrug resistance (MDR) …

Applications of Fluorous Porphyrinoids: An Update

A Aggarwal, NVSDK Bhupathiraju… - Photochemistry and …, 2021 - Wiley Online Library
Porphyrins and related macrocycles have been studied broadly for their applications in
medicine and materials because of their tunable physicochemical, optoelectronic and …