Mutations in non-coding regulatory DNA sequences can alter gene expression, organismal
phenotype and fitness,–. Constructing complete fitness landscapes, in which DNA …

Regulation of gene expression is central to many biological processes. Although
reconstruction of regulatory circuits from genomic data alone is therefore desirable, this …

Transcriptional enhancers play a key role in the initiation and maintenance of gene
expression programmes, particularly in metazoa. How these elements control their target …

We introduce a novel computational approach, CoReCo, for comparative metabolic
reconstruction and provide genome-scale metabolic network models for 49 important fungal …

Transcription factor binding sites (TFBSs) on the DNA are generally accepted as the key
nodes of gene control. However, the multitudes of TFBSs identified in genome‐wide studies …

Divergence in gene regulation can play a major role in evolution. Here, we used a
phylogenetic framework to measure mRNA profiles in 15 yeast species from the phylum …

Transcription factors (TFs) play key roles in cellular regulation and are critical in the control
of drug resistance in the fungal pathogen Candida albicans. We found that activation of the …

The binding of transcription regulators to cis-regulatory sequences is a key step through
which all cells regulate expression of their genes. Due to gains and losses of cis-regulatory …

Src homology 3 (SH3) domains bind peptides to mediate protein–protein interactions that
assemble and regulate dynamic biological processes. We surveyed the repertoire of SH3 …

MicroRNAs (miRNAs) control the abundance of the majority of the vertebrate transcriptome.
The recognition sequences, or target sites, for bilaterian miRNAs are found predominantly in …