The Mcm complex: unwinding the mechanism of a replicative helicase
ML Bochman, A Schwacha - Microbiology and Molecular Biology …, 2009 - Am Soc Microbiol
The Mcm2-7 complex serves as the eukaryotic replicative helicase, the molecular motor that
both unwinds duplex DNA and powers fork progression during DNA replication. Consistent …
both unwinds duplex DNA and powers fork progression during DNA replication. Consistent …
Archaeal DNA replication
DNA replication is essential for all life forms. Although the process is fundamentally
conserved in the three domains of life, bioinformatic, biochemical, structural, and genetic …
conserved in the three domains of life, bioinformatic, biochemical, structural, and genetic …
Unwinding the structure and function of the archaeal MCM helicase
During chromosomal DNA replication, the replicative helicase unwinds the duplex DNA to
provide the single‐stranded DNA substrate for the polymerase. In archaea, the replicative …
provide the single‐stranded DNA substrate for the polymerase. In archaea, the replicative …
Thermococcus kodakarensis encodes three MCM homologs but only one is essential
M Pan, TJ Santangelo, Z Li, JN Reeve… - Nucleic acids …, 2011 - academic.oup.com
The minichromosome maintenance (MCM) complex is thought to function as the replicative
helicase in archaea and eukaryotes. In eukaryotes, this complex is an assembly of six …
helicase in archaea and eukaryotes. In eukaryotes, this complex is an assembly of six …
Activation of the MCM helicase from the thermophilic archaeon, Thermoplasma acidophilum by interactions with GINS and Cdc6-2
H Ogino, S Ishino, GT Haugland, NK Birkeland… - Extremophiles, 2014 - Springer
In DNA replication studies, the mechanism for regulation of the various steps from initiation
to elongation is a crucial subject to understand cell cycle control. The eukaryotic …
to elongation is a crucial subject to understand cell cycle control. The eukaryotic …
The GINS complex from the thermophilic archaeon, Thermoplasma acidophilum may function as a homotetramer in DNA replication
H Ogino, S Ishino, K Mayanagi, GT Haugland… - Extremophiles, 2011 - Springer
The eukaryotic GINS heterotetramer, consisting of Sld5, Psf1, Psf2, and Psf3, participates in
“CMG complex” formation with mini-chromosome maintenance (MCM) and Cdc45 as a key …
“CMG complex” formation with mini-chromosome maintenance (MCM) and Cdc45 as a key …
Characterization of the replication initiator Orc1/Cdc6 from the Archaeon Picrophilus torridus
J Arora, K Goswami, S Saha - Journal of bacteriology, 2014 - Am Soc Microbiol
Eukaryotic DNA replication is preceded by the assembly of prereplication complexes (pre-
RCs) at or very near origins in G1 phase, which licenses origin firing in S phase. The …
RCs) at or very near origins in G1 phase, which licenses origin firing in S phase. The …
The 1.8-Å crystal structure of the N-terminal domain of an archaeal MCM as a right-handed filament
Y Fu, IM Slaymaker, J Wang, G Wang… - Journal of molecular …, 2014 - Elsevier
Mini-chromosome maintenance (MCM) proteins are the replicative helicase necessary for
DNA replication in both eukarya and archaea. Most of archaea only have one MCM gene …
DNA replication in both eukarya and archaea. Most of archaea only have one MCM gene …
Protein-protein interactions in the archaeal core replisome.
SA MacNeill - Biochemical Society transactions, 2011 - europepmc.org
Most of the core components of the archaeal chromosomal DNA replication apparatus share
significant protein sequence similarity with eukaryotic replication factors, making the …
significant protein sequence similarity with eukaryotic replication factors, making the …
Characterization of the MCM homohexamer from the thermoacidophilic euryarchaeon Picrophilus torridus
K Goswami, J Arora, S Saha - Scientific Reports, 2015 - nature.com
The typical archaeal MCM exhibits helicase activity independently in vitro. This study
characterizes MCM from the euryarchaeon Picrophilus torridus. While PtMCM hydrolyzes …
characterizes MCM from the euryarchaeon Picrophilus torridus. While PtMCM hydrolyzes …