Squalene is a natural lipid belonging to the terpenoid family and a precursor of cholesterol
biosynthesis. It is synthesized in humans and also in a wide array of organisms and …

The large subunit of human ribonucleotide reductase, RRM1, is involved in the regulation of
cell proliferation, cell migration, tumour and metastasis development, and the synthesis of …

Nanomedicines suffer from poor drug loading and uncontrolled 'burst release'after
administration. Combining prodrug strategies with nanostructured carriers can help to …

Squalene is a triterpene widely distributed in nature that is an intermediate in the cholesterol
biosynthesis pathway. The remarkable dynamic folded conformation of squalene has been …

Gemcitabine has been extensively applied in treating various solid tumors. Nonetheless, the
clinical performance of gemcitabine is severely restricted by its unsatisfactory …

Self-assembled prodrugs forming nanoaggregates are a promising approach to enhance
the antitumor efficacy and to reduce the toxicity of anticancer drugs. To achieve this goal …

Some approaches to enhance the entrapment efficiency within nanoparticulate systems,
chiefly of hydrophilic molecules, developed mainly by the Turin University Pharmaceutical …

We have designed an amphiphilic prodrug of gemcitabine (dFdC) by its covalent coupling to
a derivative of squalene, a natural lipid. The resulting bioconjugate self-assembled …

Nanotechnology provides a broad range of opportunities to develop new solutions for
clinical problems. For the pulmonary field, nanotechnology promises better delivery of drugs …

Despite recent advances in targeted therapies and immunotherapies, chemotherapy using
cytotoxic agents remains an indispensable modality in cancer treatment. Recently, there has …