Distinct genome replication and transcription strategies within the growing filovirus family

AJ Hume, E Mühlberger - Journal of molecular biology, 2019 - Elsevier
Research on filoviruses has historically focused on the highly pathogenic ebola-and
marburgviruses. Indeed, until recently, these were the only two genera in the filovirus family …

Current status of small molecule drug development for Ebola virus and other filoviruses

MR Edwards, CF Basler - Current opinion in virology, 2019 - Elsevier
The filovirus family includes some of the deadliest viruses known, including Ebola virus and
Marburg virus. These viruses cause periodic outbreaks of severe disease that can be spread …

Phosphorylation of VP1 mediated by CDK1-cyclin B1 facilitates infectious bursal disease virus replication

X Hu, Z Chen, X Wu, Z Ding, Y Huang, Q Fu… - Journal of …, 2023 - Am Soc Microbiol
Infectious bursal disease virus (IBDV) is a double-stranded RNA (dsRNA) virus belonging to
the genus Avibirnavirus in the family Birnaviridae. It can cause serious failure of vaccination …

The cellular protein phosphatase 2A is a crucial host factor for Marburg virus transcription

I von Creytz, C Rohde, N Biedenkopf - Journal of Virology, 2024 - journals.asm.org
Little is known regarding the molecular mechanisms that highly pathogenic Marburg virus
(MARV) utilizes to transcribe and replicate its genome. Previous studies assumed that …

Mining of marburg virus proteome for designing an epitope-based vaccine

MA Soltan, WK Abdulsahib, M Amer… - Frontiers in …, 2022 - frontiersin.org
Marburg virus (MARV) is one of the most harmful zoonotic viruses with deadly effects on
both humans and nonhuman primates. Because of its severe outbreaks with a high rate of …

PP2A phosphatase as an emerging viral host factor

MS Barski, JJ Minnell, GN Maertens - Frontiers in Cellular and …, 2021 - frontiersin.org
Protein phosphatase 2A (PP2A) is one of the most ubiquitous cellular proteins and is
responsible for the vast majority of Ser/Thr phosphatase activity in eukaryotes. PP2A is a …

Assessment of life cycle modeling systems as prediction tools for a possible attenuation of recombinant Ebola viruses

BS Bodmer, T Hoenen - Viruses, 2022 - mdpi.com
Ebola virus (EBOV) causes hemorrhagic fever in humans with high case fatality rates. In the
past, a number of recombinant EBOVs expressing different reporters from additional …

Respiratory syncytial virus phosphoprotein residue S156 plays a role in regulating genome transcription and replication

AC Beavis, KC Tran, ER Barrozo, SI Phan… - Journal of …, 2021 - Am Soc Microbiol
Respiratory syncytial virus (RSV) is a single-stranded, negative-sense RNA virus in the
family Pneumoviridae and genus Orthopneumovirus that can cause severe disease in …

[HTML][HTML] Phosphorylation controls RNA binding and transcription by the influenza virus polymerase

AR Dawson, GM Wilson, EC Freiberger… - PLoS …, 2020 - journals.plos.org
The influenza virus polymerase transcribes and replicates the viral genome. The proper
timing and balance of polymerase activity is important for successful replication. Genome …

Ebola virus produces discrete small noncoding RNAs independently of the host microRNA pathway which lack RNA interference activity in bat and human cells

AN Prasad, AJ Ronk, SG Widen, TG Wood… - Journal of …, 2020 - Am Soc Microbiol
The question as to whether RNA viruses produce bona fide microRNAs (miRNAs) during
infection has been the focus of intense research and debate. Recently, several groups using …