Rare molecular subtypes of lung cancer
Oncogenes that occur in≤ 5% of non-small-cell lung cancers have been defined as 'rare';
nonetheless, this frequency can correspond to a substantial number of patients diagnosed …
nonetheless, this frequency can correspond to a substantial number of patients diagnosed …
A review on the effect of COX-2-mediated mechanisms on development and progression of gastric cancer induced by nicotine
Y Xu, J Wang, Z He, Z Rao, Z Zhang, J Zhou… - Biochemical …, 2024 - Elsevier
Smoking is a documented risk factor for cancer, eg, gastric cancer. Nicotine, the principal
tobacco alkaloid, would exert its role of contribution to gastric cancer development and …
tobacco alkaloid, would exert its role of contribution to gastric cancer development and …
Synthesis of N-(4-chlorophenyl) substituted pyrano[2,3-c]pyrazoles enabling PKBβ/AKT2 inhibitory and in vitro anti-glioma activity
Abstract A series of N-(4-chlorophenyl) substituted pyrano [2, 3-c] pyrazoles was
synthesised and screened for their potential to inhibit kinases and exhibit anticancer activity …
synthesised and screened for their potential to inhibit kinases and exhibit anticancer activity …
Mislocalization of protein kinase A drives pathology in Cushing's syndrome
Mutations in the catalytic subunit of protein kinase A (PKAc) drive the stress hormone
disorder adrenal Cushing's syndrome. We define mechanisms of action for the PKAc-L205R …
disorder adrenal Cushing's syndrome. We define mechanisms of action for the PKAc-L205R …
Conventional protein kinase C in the brain: repurposing cancer drugs for neurodegenerative treatment?
G Lordén, AC Newton - Neuronal signaling, 2021 - portlandpress.com
Abstract Protein Kinase C (PKC) isozymes are tightly regulated kinases that transduce a
myriad of signals from receptor-mediated hydrolysis of membrane phospholipids. They play …
myriad of signals from receptor-mediated hydrolysis of membrane phospholipids. They play …
Protein kinase C: release from quarantine by mTORC2
Protein kinase C (PKC) isozymes are maintained in a'ready-to-go'but'safe'autoinhibited
conformation until second messenger binding unleashes an autoinhibitory pseudosubstrate …
conformation until second messenger binding unleashes an autoinhibitory pseudosubstrate …
Mutations in protein kinase Cγ promote spinocerebellar ataxia type 14 by impairing kinase autoinhibition
Spinocerebellar ataxia type 14 (SCA14) is a neurodegenerative disease caused by
germline variants in the diacylglycerol (DAG)/Ca2+-regulated protein kinase Cγ (PKCγ) …
germline variants in the diacylglycerol (DAG)/Ca2+-regulated protein kinase Cγ (PKCγ) …
Endogenous hydrogen peroxide positively regulates secretion of a gut-derived peptide in neuroendocrine potentiation of the oxidative stress response in …
Q Jia, D Young, Q Zhang, D Sieburth - Elife, 2024 - elifesciences.org
The gut-brain axis mediates bidirectional signaling between the intestine and the nervous
system and is critical for organism-wide homeostasis. Here, we report the identification of a …
system and is critical for organism-wide homeostasis. Here, we report the identification of a …
Sinonasal adenosquamous carcinomas arising in seromucinous hamartoma or respiratory epithelial adenomatoid hamartoma with atypical features: Report of five …
M Bradová, V Costes‐Martineau, J Laco… - …, 2024 - Wiley Online Library
Aims Sinonasal adenosquamous carcinoma (ASC) is a rare tumour classified as a variant of
squamous cell carcinoma, exhibiting both squamous and glandular differentiation. ASC has …
squamous cell carcinoma, exhibiting both squamous and glandular differentiation. ASC has …
Cancer-associated mutations in protein kinase C theta are loss-of-function
The Ca2+-independent, but diacylglycerol-regulated, novel protein kinase C (PKC) theta (θ)
is highly expressed in hematopoietic cells where it participates in immune signaling and …
is highly expressed in hematopoietic cells where it participates in immune signaling and …