Aim Ischemic damage to the brain is linked to an increased rate of morbidity and mortality
worldwide. In certain parts of the world, it remains a leading cause of mortality and the …

Despite the significant decline in mortality, cardiovascular diseases are still the leading
cause of death worldwide. Among them, myocardial infarction (MI) seems to be the most …

The mechanisms underlying the development of neuropathy associated with diabetes
mellitus are not fully understood. Resveratrol, as a nonflavonoid polyphenol, plays a variety …

Huntington's disease (HD) is an autosomal dominant inherited neurodegenerative disease
characterized by progressive motor, psychiatric, and cognitive abnormalities. The …

Type 2 diabetes mellitus is a disease associated with an oxidative milieu that often leads to
adverse health outcomes. Multiple anthocyanins have been reported to possess outstanding …

Oxidative stress has been described as a key driver of Leydig cell apoptosis. Melatonin has
antioxidative and antiapoptotic effects, but the potential effects and mechanism of melatonin …

Ischemic stroke is the most common type of cerebrovascular disease with high disability and
mortality rates, which severely burdens patients, their families, and society. At present …

Myocardial infarction is one of the most serious fatal diseases in the world, which is due to
acute occlusion of coronary arteries. Grape seed proanthocyanidin extract (GSPE) is an …

Patients with high-frequency resistant migraine and medication-overuse headache are still
the main clinical challenge in tertiary headache centers. The approval of targeted antibodies …

Aims Calcitonin gene-related peptide (CGRP) is a pluripotent neuropeptide crucial for
maintaining vascular homeostasis, yet its full therapeutic potential remains incompletely …