Urolithin A (UA) is a natural compound produced by gut bacteria from ingested ellagitannins
(ETs) and ellagic acid (EA), complex polyphenols abundant in foods such as pomegranate …

The Keap1/Nrf2/ARE system is a central defensive mechanism against oxidative stress
which plays a key role in the pathogenesis and progression of many diseases. Nrf2 is a …

Osteoarthritis (OA) is the most common age‐related joint disorder with no effective therapy.
According to the World Health Organization, OA affects over 500 million people and is …

Targeting mitophagy to activate the recycling of faulty mitochondria during aging is a
strategy to mitigate muscle decline. We present results from a randomized, placebo …

Foods rich in ellagic tannins are first hydrolyzed into ellagic acid in the stomach and small
intestine, and then converted into urolithins with high bioavailability by the intestinal flora …

Inflammation is a physiological process involved in the defenses of the body and the repair
of tissues. It is acutely activated by infections, trauma, toxins, or allergic reactions. However …

Oxidative stress is a state of excess of prooxidative species relative to the antioxidant
defenses (enzymatic and nonenzymatic) in a living organism. The consequence of this …

Urolithins, metabolites produced by the gut microbiota from the polyphenols ellagitannins
and ellagic acid, are discovered by the research group in humans almost 20 years ago …

Acute lung injury (ALI), a severe and life-threatening inflammation of the lung, with high
morbidity and mortality, underscoring the urgent need for novel treatments. Ge-Gen-Qin-Lian …

Urolithin A (UroA) is a microbial metabolite derived from ellagitannins and ellagic acid with
good bioavailability. In this study, we explored the anticolitis activity of UroA and clarified the …