Unpredicted human safety events in clinical trials for new drugs are costly in terms of human
health and money. The drug discovery industry attempts to minimize those events with …

The occurrence of neuroactive chemicals in the aquatic environment is on the rise and
poses a potential threat to aquatic biota of currently unpredictable outcome. In particular …

Abstract Background The Fish Embryo Acute Toxicity (FET) test with the zebrafish (Danio
rerio) embryo, the OECD test guideline (TG) 236, has been designed as an alternative for …

Nonclinical testing of human pharmaceuticals is conducted to assess the safety of
compounds to be studied in human clinical trials and for marketing of new drugs. Although …

Originally designed as an alternative for the acute fish toxicity test according to, eg, OECD
TG 203, the fish embryo test (FET) with the zebrafish (Danio rerio) has been optimized …

Polycyclic aromatic hydrocarbons (PAHs) are widespread environmental contaminants that
occur in complex mixtures. Several PAHs are known or suspected mutagens and/or …

Perfluoroalkyl substances (PFAS) are a class of synthetic chemicals that are persistent in the
environment. Due to adverse health outcomes associated with longer chain PFAS, shorter …

Abstract Purpose of Review Organophosphate esters (OPEs) are applied to a variety of
consumer products, primarily as flame retardants and plasticizers. OPEs can leach out of …

The zebrafish is increasingly used as a vertebrate animal model for in vivo drug discovery
and for assessing chemical toxicity and safety. Numerous studies have confirmed that …

Neurotransmission is the basis of neuronal communication and is critical for normal brain
development, behavior, learning, and memory. Exposure to drugs and chemicals can alter …