1.1. General Heterocyclic compounds, especially nitrogen heterocycles, are the most
important class of compounds in the pharmaceutical and agrochemical industries, with …

Cysteine proteases continue to provide validated targets for treatment of human diseases. In
neurodegenerative disorders, multiple cysteine proteases provide targets for enzyme …

Caspases are proteases at the heart of networks that govern apoptosis and inflammation.
The past decade has seen huge leaps in understanding the biology and chemistry of the …

Specific targeting and cellular internalization are key properties for carriers of antitumor
therapeutic agents. Here, we develop a drug carrier through the attachment of substrate of …

Abstract α, β‐Unsaturated carbonyl compounds as potential drug candidates is a
controversial topic since their potential Michael acceptor activity can lead to cell damage …

Azapeptides are peptide analogs in which one or more of the amino residues is replaced by
a semicarbazide. This substitution of a nitrogen for the α-carbon center results in …

Cysteine proteases selectively catalyze the hydrolysis of peptide bonds. Uncontrolled,
unregulated, or undesired proteolysis can lead to many disease states including …

Caspase proteases are principal mediators of apoptosis, where they cleave hundreds of
proteins. Phosphorylation also plays an important role in apoptosis, although the extent to …

Caspases, a family of cysteine proteases, are major mediators of apoptosis and
inflammation. Caspase-6 is classified as an apoptotic effector, and it mediates nuclear …

Caspases are proteases of clan CD and were described for the first time more than two
decades ago. They play critical roles in the control of regulated cell death pathways …