Malaria remains a significant contributor to the global burden of disease, with around 40% of
the world's population at risk of Plasmodium infections. The development of an effective …

The quest for a licensed effective vaccine against malaria remains a global priority. Even
though classical vaccine design strategies have been successful for some viral and bacterial …

Naturally acquired immunity (NAI) to Plasmodium falciparum malaria is mainly mediated by
IgG antibodies but the subclasses, epitope targets and effector functions have not been …

A vaccine remains a priority in the global fight against malaria. Here, we report on a single-
center, randomized, double-blind, placebo and adjuvant-controlled, dose escalation phase …

The study of antigenic targets of naturally-acquired immunity is essential to identify and
prioritize antigens for further functional characterization. We measured total IgG antibodies …

Blood phagocytes, such as neutrophils and monocytes, generate reactive oxygen species
(ROS) as a part of host defense response against infections. We investigated the …

Malaria is a widespread disease caused mainly by the Plasmodium falciparum (Pf) and
Plasmodium vivax (Pv) protozoan parasites. Depending on the parasite responsible for the …

Introduction A vaccine would greatly accelerate current global efforts toward malaria
elimination. While a partially efficacious vaccine has been achieved for Plasmodium …

Background The specific targets of functional antibodies against Plasmodium falciparum
merozoites remain largely unexplored and, more importantly, their relevance to naturally …

Background The collection of clinical data from a tribal population in a malaria-endemic area
of India suggests the occurrence of naturally acquired immunity (NAI) against Plasmodium …