Adeno-associated virus toolkit to target diverse brain cells
RC Challis, S Ravindra Kumar, X Chen… - Annual review of …, 2022 - annualreviews.org
Recombinant adeno-associated viruses (AAVs) are commonly used gene delivery vehicles
for neuroscience research. They have two engineerable features: the capsid (outer protein …
for neuroscience research. They have two engineerable features: the capsid (outer protein …
Fluorescence imaging of large-scale neural ensemble dynamics
TH Kim, MJ Schnitzer - Cell, 2022 - cell.com
Recent progress in fluorescence imaging allows neuroscientists to observe the dynamics of
thousands of individual neurons, identified genetically or by their connectivity, across …
thousands of individual neurons, identified genetically or by their connectivity, across …
A red light–responsive photoswitch for deep tissue optogenetics
Y Kuwasaki, K Suzuki, G Yu, S Yamamoto… - Nature …, 2022 - nature.com
Red light penetrates deep into mammalian tissues and has low phototoxicity, but few
optogenetic tools that use red light have been developed. Here we present MagRed, a red …
optogenetic tools that use red light have been developed. Here we present MagRed, a red …
Neurobiology of cannabinoid receptor signaling
B Lutz - Dialogues in clinical neuroscience, 2020 - Taylor & Francis
The endocannabinoid system (ECS) is a highly versatile signaling system within the nervous
system. Despite its widespread localization, its functions within the context of distinct neural …
system. Despite its widespread localization, its functions within the context of distinct neural …
Optogenetics for transcriptional programming and genetic engineering
Optogenetics combines genetics and biophotonics to enable noninvasive control of
biological processes with high spatiotemporal precision. When engineered into protein …
biological processes with high spatiotemporal precision. When engineered into protein …
Microcircuits for spatial coding in the medial entorhinal cortex
The hippocampal formation is critically involved in learning and memory and contains a
large proportion of neurons encoding aspects of the organism's spatial surroundings. In the …
large proportion of neurons encoding aspects of the organism's spatial surroundings. In the …
Strategies for site-specific recombination with high efficiency and precise spatiotemporal resolution
X Tian, B Zhou - Journal of Biological Chemistry, 2021 - ASBMB
Site-specific recombinases (SSRs) are invaluable genome engineering tools that have
enormously boosted our understanding of gene functions and cell lineage relationships in …
enormously boosted our understanding of gene functions and cell lineage relationships in …
A toolbox of astrocyte-specific, serotype-independent adeno-associated viral vectors using microRNA targeting sequences
Astrocytes, one of the most prevalent cell types in the central nervous system (CNS), are
critically involved in neural function. Genetically manipulating astrocytes is an essential tool …
critically involved in neural function. Genetically manipulating astrocytes is an essential tool …
CORNN: Convex optimization of recurrent neural networks for rapid inference of neural dynamics
Advances in optical and electrophysiological recording technologies have made it possible
to record the dynamics of thousands of neurons, opening up new possibilities for interpreting …
to record the dynamics of thousands of neurons, opening up new possibilities for interpreting …
A novel Flp reporter mouse shows that TRPA1 expression is largely limited to sensory neuron subsets
Transient receptor potential ankyrin 1 (TRPA1) is a polymodal cation channel that is
activated by electrophilic irritants, oxidative stress, cold temperature, and GPCR signaling …
activated by electrophilic irritants, oxidative stress, cold temperature, and GPCR signaling …