Molecular mechanisms and consequences of mitochondrial permeability transition
Mitochondrial permeability transition (mPT) is a phenomenon that abruptly causes the flux of
low molecular weight solutes (molecular weight up to 1,500) across the generally …
low molecular weight solutes (molecular weight up to 1,500) across the generally …
Modulating glycolysis to improve cancer therapy
Cancer cells undergo metabolic reprogramming and switch to a 'glycolysis-
dominant'metabolic profile to promote their survival and meet their requirements for energy …
dominant'metabolic profile to promote their survival and meet their requirements for energy …
Reprogramming glucose metabolism in cancer: can it be exploited for cancer therapy?
N Hay - Nature Reviews Cancer, 2016 - nature.com
In recent years there has been a growing interest among cancer biologists in cancer
metabolism. This Review summarizes past and recent advances in our understanding of the …
metabolism. This Review summarizes past and recent advances in our understanding of the …
Mitochondrial and endoplasmic reticulum calcium homeostasis and cell death
The endoplasmic reticulum (ER) and mitochondria cannot be considered as static structures,
as they intimately communicate, forming very dynamic platforms termed mitochondria …
as they intimately communicate, forming very dynamic platforms termed mitochondria …
Mitochondrial control of microglial phagocytosis by the translocator protein and hexokinase 2 in Alzheimer's disease
Microglial phagocytosis is an energetically demanding process that plays a critical role in
the removal of toxic protein aggregates in Alzheimer's disease (AD). Recent evidence …
the removal of toxic protein aggregates in Alzheimer's disease (AD). Recent evidence …
The ERK and JNK pathways in the regulation of metabolic reprogramming
Most tumor cells reprogram their glucose metabolism as a result of mutations in oncogenes
and tumor suppressors, leading to the constitutive activation of signaling pathways involved …
and tumor suppressors, leading to the constitutive activation of signaling pathways involved …
Hexokinase 2 in cancer: a prima donna playing multiple characters
Hexokinases are a family of ubiquitous exose-phosphorylating enzymes that prime glucose
for intracellular utilization. Hexokinase 2 (HK2) is the most active isozyme of the family …
for intracellular utilization. Hexokinase 2 (HK2) is the most active isozyme of the family …
Metabolic reprogramming in clear cell renal cell carcinoma
HI Wettersten, OA Aboud, PN Lara Jr… - Nature Reviews …, 2017 - nature.com
Research in many cancers has uncovered changes in metabolic pathways that control
tumour energetics and biosynthesis, so-called metabolic reprogramming. Studies in clear …
tumour energetics and biosynthesis, so-called metabolic reprogramming. Studies in clear …
T cell metabolism drives immunity
Lymphocytes must adapt to a wide array of environmental stressors as part of their normal
development, during which they undergo a dramatic metabolic remodeling process …
development, during which they undergo a dramatic metabolic remodeling process …
The mitochondrial permeability transition pore: channel formation by F-ATP synthase, integration in signal transduction, and role in pathophysiology
P Bernardi, A Rasola, M Forte… - Physiological …, 2015 - journals.physiology.org
The mitochondrial permeability transition (PT) is a permeability increase of the inner
mitochondrial membrane mediated by a channel, the permeability transition pore (PTP) …
mitochondrial membrane mediated by a channel, the permeability transition pore (PTP) …