The central role of tau in Alzheimer's disease: From neurofibrillary tangle maturation to the induction of cell death
DR Thal, SO Tomé - Brain Research Bulletin, 2022 - Elsevier
The tau protein (τ) is one of the two hallmark proteins of Alzheimer's disease (AD) together
with the amyloid β protein (Aβ). In contrast to Aβ, abnormally phosphorylated τ (p-τ) can also …
with the amyloid β protein (Aβ). In contrast to Aβ, abnormally phosphorylated τ (p-τ) can also …
The spectrum of cognitive dysfunction in amyotrophic lateral sclerosis: an update
KA Jellinger - International Journal of Molecular Sciences, 2023 - mdpi.com
Cognitive dysfunction is an important non-motor symptom in amyotrophic lateral sclerosis
(ALS) that has a negative impact on survival and caregiver burden. It shows a wide spectrum …
(ALS) that has a negative impact on survival and caregiver burden. It shows a wide spectrum …
TDP-43 pathology is associated with increased tau burdens and seeding
SO Tomé, G Tsaka, A Ronisz, S Ospitalieri… - Molecular …, 2023 - Springer
Abstract Background Most Alzheimer's Disease (AD) cases also exhibit limbic predominant
age-related TDP-43 encephalopathy neuropathological changes (LATE-NC), besides …
age-related TDP-43 encephalopathy neuropathological changes (LATE-NC), besides …
LATE-NC aggravates GVD-mediated necroptosis in Alzheimer's disease
MJ Koper, SO Tomé, K Gawor, A Belet… - Acta Neuropathologica …, 2022 - Springer
It has become evident that Alzheimer's Disease (AD) is not only linked to its hallmark lesions—
amyloid plaques and neurofibrillary tangles (NFTs)—but also to other co-occurring …
amyloid plaques and neurofibrillary tangles (NFTs)—but also to other co-occurring …
LATE‐NC in Alzheimer's disease: Molecular aspects and synergies
Alzheimer's disease (AD) is classically characterized by senile plaques and neurofibrillary
tangles (NFTs). However, multiple copathologies can be observed in the AD brain and …
tangles (NFTs). However, multiple copathologies can be observed in the AD brain and …
Aβ1-6A2V(D) peptide, effective on Aβ aggregation, inhibits tau misfolding and protects the brain after traumatic brain injury
Abstract Alzheimer's disease (AD), the leading cause of dementia in older adults, is a double
proteinopathy characterized by amyloid-β (Aβ) and tau pathology. Despite enormous efforts …
proteinopathy characterized by amyloid-β (Aβ) and tau pathology. Despite enormous efforts …
Grey matter ageing-related tau astrogliopathy: associations with brain pathologies and cognitive decline
Grey matter ageing-related tau astrogliopathy (ARTAG) pathology is common in aged brains
and detected in multiple brain regions. However, the associations of grey matter ARTAG with …
and detected in multiple brain regions. However, the associations of grey matter ARTAG with …
Neurotoxicity Evaluation of Nanomaterials Using C. elegans: Survival, Locomotion Behaviors, and Oxidative Stress
Nanomaterials are broadly used in a variety of industries and consumer products. However,
studies have demonstrated that many nanomaterials, including metal‐containing …
studies have demonstrated that many nanomaterials, including metal‐containing …
[HTML][HTML] The unique neuropathological vulnerability of the human brain to aging
I Ferrer - Ageing Research Reviews, 2023 - Elsevier
Abstract Alzheimer's disease (AD)-related neurofibrillary tangles (NFT), argyrophilic grain
disease (AGD), aging-related tau astrogliopathy (ARTAG), limbic predominant TDP-43 …
disease (AGD), aging-related tau astrogliopathy (ARTAG), limbic predominant TDP-43 …
[HTML][HTML] Transcriptomic evaluation of tau and TDP-43 synergism shows tauopathy predominance and reveals potential modulating targets
Abstract Alzheimer's disease (AD), the most common aging-associated neurodegenerative
dementia disorder, is defined by the presence of amyloid beta (Aβ) and tau aggregates in …
dementia disorder, is defined by the presence of amyloid beta (Aβ) and tau aggregates in …