Highlights•Mutant K13-mediated artemisinin resistance involves reduced hemoglobin
endocytosis.•Artemisinin partial resistance has emerged in Africa.•Novel PfCRT mutations …

Malaria, mostly due to Plasmodium falciparum infection in Africa, remains one of the most
important infectious diseases in the world. Standard treatment for uncomplicated P …

Background Although the clinical efficacy of antimalarial artemisinin-based combination
therapies in Africa remains high, the recent emergence of partial resistance to artemisinin in …

Abstract Background Partial resistance of Plasmodium falciparum to the artemisinin
component of artemisinin-based combination therapies, the most important malaria drugs …

Abstract Background In the six Southeast Asian countries that make up the Greater Mekong
Subregion, Plasmodium falciparum has developed resistance to derivatives of artemisinin …

Background Partial artemisinin resistance is suspected if delayed parasite clearance (ie,
persistence of parasitaemia on day 3 after treatment initiation) is observed. Validated …

Malaria cases and deaths remain unacceptably high and are resurgent in several settings,
though recent developments inspire optimism. This includes the approval of the world's first …

Artemisinin partial resistance may facilitate selection of Plasmodium falciparum resistant to
combination therapy partner drugs. We evaluated 99 P. falciparum isolates collected in 2021 …

The emergence of mutant K13-mediated artemisinin (ART) resistance in Plasmodium
falciparum malaria parasites has led to widespread treatment failures across Southeast …

Page 1 World malaria וייוייו report 2023 wwwwww World Health Organization Page 2 World
malaria report 2023 ISBN 978-92-4-008617-3 (electronic version) ISBN 978-92-4-008618-0 …