Viral G Protein–Coupled Receptors Encoded by β-and γ-Herpesviruses

MM Rosenkilde, N Tsutsumi, JM Knerr… - Annual review of …, 2022 - annualreviews.org
Herpesviruses are ancient large DNA viruses that have exploited gene capture as part of
their strategy to escape immune surveillance, promote virus spreading, or reprogram host …

Current status and future potential of ex vivo lung perfusion in clinical lung transplantation

AL Zhou, EL Larson, JM Ruck, JS Ha… - Artificial …, 2023 - Wiley Online Library
Lung transplantation is accepted as a well‐established and effective treatment for patients
with end‐stage lung disease. While the number of candidates added to the waitlist continues …

De novo design and development of a nutrient-rich perfusate for ex vivo lung perfusion with cell culture models

L Huang, RN Vellanki, Z Zhu, BG Wouters… - International Journal of …, 2023 - mdpi.com
Ex vivo lung perfusion (EVLP) has increased donor lung utilization through assessment of
“marginal” lungs prior to transplantation. To develop it as a donor lung reconditioning …

Complement-targeting therapeutics for ischemia-reperfusion injury in transplantation and the potential for ex vivo delivery

IF Delaura, Q Gao, IJ Anwar, N Abraham… - Frontiers in …, 2022 - frontiersin.org
Organ shortages and an expanding waitlist have led to increased utilization of marginal
organs. All donor organs are subject to varying degrees of IRI during the transplant process …

Diagnostic and therapeutic implications of ex vivo lung perfusion in lung transplantation: potential benefits and inherent limitations

J Yu, N Zhang, Z Zhang, Y Li, J Gao, C Chen… - Transplantation, 2023 - journals.lww.com
Ex vivo lung perfusion (EVLP), a technique in which isolated lungs are continually ventilated
and perfused at normothermic temperature, is emerging as a promising platform to optimize …

The role of ex-situ perfusion for thoracic organs

MJ Roesel, B Wiegmann, F Ius… - Current Opinion in …, 2022 - journals.lww.com
The role of ex-situ perfusion for thoracic organs : Current Opinion in Organ Transplantation The
role of ex-situ perfusion for thoracic organs : Current Opinion in Organ Transplantation Log in or …

Insight into structural properties of viral G protein‐coupled receptors and their role in the viral infection: IUPHAR Review 41

N Tsutsumi, DF Kildedal, OK Hansen… - British Journal of …, 2025 - Wiley Online Library
G protein‐coupled receptors (GPCRs) are pivotal in cellular signalling and drug targeting.
Herpesviruses encode GPCRs (vGPCRs) to manipulate cellular signalling, thereby …

Therapeutic targeting of HCMV-encoded chemokine receptor US28: Progress and challenges

C Berg, MM Rosenkilde - Frontiers in Immunology, 2023 - frontiersin.org
The pervasive human cytomegalovirus (HCMV) causes significant morbidity in
immunocompromised individuals. Treatment using the current standard-of-care (SOC) is …

[HTML][HTML] Machine Perfusion Plus for Extended Criteria Donor Liver Grafts: Making Every Liver Count

Z Wang, J Martin, J Yu, K Wang, K Saeb-Parsy, X Xu - Engineering, 2024 - Elsevier
Transplantation represents the most effective treatment for end-stage liver diseases but is
limited by the shortage of healthy donor organs. Extended criteria donor (ECD) liver grafts …

Current achievements and future applications of ex vivo lung perfusion; where do we go from here?

D Van Raemdonck, LJ Ceulemans… - The Journal of Thoracic …, 2023 - jtcvs.org
Feature Editor Note—Simply speaking, the public health benefits of solid-organ
transplantation are limited by the number of suitable organs. In the last decade, however …