The circadian clock protein BMAL1 modulates glial activation and amyloid-beta deposition
in mice. However, the effects of BMAL1 on other aspects of neurodegenerative pathology …

Insoluble fibrillar tau, the primary constituent of neurofibrillary tangles, has traditionally been
thought to be the biologically active, toxic form of tau mediating neurodegeneration in …

Fermented food is commonly viewed as healthy, mostly due to its probiotic and digestion-
enhancing properties and recently it has been examined with regard to the development of …

Reactive changes of glial cells during neuroinflammation impact brain disorders and
disease progression. Elucidating the mechanisms that control reactive gliosis may help us to …

Sheehan and Nadarajah et al. 1 identified that Bmal1 loss from astrocytes induces the
expression of BAG3, a macroautophagy chaperone enriched in Alzheimer's disease patients …

In Alzheimer's disease (AD) brains, reactive astrocytes and microglia are frequently seen
around amyloid plaques. The functions of microglia have been extensively studied, such as …