Too many choices can be problematic. This is certainly the case for human pluripotent stem
cells (hPSCs): they harbor the potential to differentiate into hundreds of cell types; yet it is …

Controlling self-renewal and lineage differentiation of stem cells (SCs) is critical for SC
therapy in regenerative medicine. Multiple signal pathways such as Wnt, TGF-β and BMP …

Targeted differentiation of human induced pluripotent stem cells (hiPSCs) using only
chemicals would have value-added clinical potential in the regeneration of complex cell …

Human embryonic stem cells (hESCs) have the potential to form any cell type in the body,
making them attractive cell sources in drug screening, regenerative medicine, disease and …

Background To maximize the translational utility of human induced pluripotent stem cells
(iPSCs), the ability to precisely modulate the differentiation of iPSCs to target phenotypes is …

Pluripotent human embryonic stem cell (hESC) lines are a valuable in vitro tool to
differentiate specific cell lineages, including cells from all three germ layers, ie, neuronal …

Embryonic stem cells have the ability to self-renew or differentiate and these processes are
under tight control. We previously reported that the polyamine regulator AMD1 is critical for …

These protocols describe a detailed method to determine the DNA damage and F‐actin and
microtubule defects of metaphase II oocytes caused by hexavalent chromium, Cr (VI), an …

Background Since the regenerative medicine sector entered the second phase of its
development (RegenMed 2.0) more than a decade ago, there is increasing recognition that …

Background Mesendodermal formation during early gastrulation requires the expression of
lineage-specific genes, while the regulatory mechanisms during this process have not yet …