The ways of tails: the GET pathway and more
N Borgese, J Coy-Vergara, SF Colombo… - The Protein …, 2019 - Springer
Due to their topology tail-anchored (TA) proteins must target to the membrane independently
of the co-translational route defined by the signal sequence recognition particle (SRP), its …
of the co-translational route defined by the signal sequence recognition particle (SRP), its …
The role of EMC during membrane protein biogenesis
PJ Chitwood, RS Hegde - Trends in Cell Biology, 2019 - cell.com
Ten years ago, high-throughput genetic interaction analyses revealed an abundant and
widely conserved protein complex residing in the endoplasmic reticulum (ER) membrane …
widely conserved protein complex residing in the endoplasmic reticulum (ER) membrane …
EMC is required to initiate accurate membrane protein topogenesis
Mammals encode∼ 5,000 integral membrane proteins that need to be inserted in a defined
topology at the endoplasmic reticulum (ER) membrane by mechanisms that are incompletely …
topology at the endoplasmic reticulum (ER) membrane by mechanisms that are incompletely …
The ER membrane protein complex interacts cotranslationally to enable biogenesis of multipass membrane proteins
The endoplasmic reticulum (ER) supports biosynthesis of proteins with diverse
transmembrane domain (TMD) lengths and hydrophobicity. Features in transmembrane …
transmembrane domain (TMD) lengths and hydrophobicity. Features in transmembrane …
A conserved endoplasmic reticulum membrane protein complex (EMC) facilitates phospholipid transfer from the ER to mitochondria
Mitochondrial membrane biogenesis and lipid metabolism require phospholipid transfer
from the endoplasmic reticulum (ER) to mitochondria. Transfer is thought to occur at regions …
from the endoplasmic reticulum (ER) to mitochondria. Transfer is thought to occur at regions …
Structure of the ER membrane complex, a transmembrane-domain insertase
The endoplasmic reticulum (ER) membrane complex (EMC) cooperates with the Sec61
translocon to co-translationally insert a transmembrane helix (TMH) of many multi-pass …
translocon to co-translationally insert a transmembrane helix (TMH) of many multi-pass …
Structural and mechanistic basis of the EMC-dependent biogenesis of distinct transmembrane clients
Membrane protein biogenesis in the endoplasmic reticulum (ER) is complex and failure-
prone. The ER membrane protein complex (EMC), comprising eight conserved subunits, has …
prone. The ER membrane protein complex (EMC), comprising eight conserved subunits, has …
The architecture of EMC reveals a path for membrane protein insertion
Approximately 25% of eukaryotic genes code for integral membrane proteins that are
assembled at the endoplasmic reticulum. An abundant and widely conserved multi-protein …
assembled at the endoplasmic reticulum. An abundant and widely conserved multi-protein …
Squaring the EMC–how promoting membrane protein biogenesis impacts cellular functions and organismal homeostasis
N Volkmar, JC Christianson - Journal of cell science, 2020 - journals.biologists.com
Integral membrane proteins play key functional roles at organelles and the plasma
membrane, necessitating their efficient and accurate biogenesis to ensure appropriate …
membrane, necessitating their efficient and accurate biogenesis to ensure appropriate …
A yeast phenomic model for the gene interaction network modulating CFTR-ΔF508 protein biogenesis
Background The overall influence of gene interaction in human disease is unknown. In
cystic fibrosis (CF) a single allele of the cystic fibrosis transmembrane conductance regulator …
cystic fibrosis (CF) a single allele of the cystic fibrosis transmembrane conductance regulator …