Now 30 years old, the chronic mild stress (CMS) model of depression has been used in>
1300 published studies, with a year-on-year increase rising to> 200 papers in 2015. Data …

Schizophrenia is a severe mental illness that affects almost 1% of the population worldwide.
Even though the etiology of schizophrenia is uncertain, it is believed to be a …

N-methyl-d-aspartate receptors (NMDARs) are located in neuronal cell membranes at
synaptic and extrasynaptic locations, where they are believed to mediate distinct …

N-methyl-D-aspartate receptors (NMDARs) are glutamate-gated ion channels widely
expressed in the central nervous system that play key role in brain development and …

The two amino acids GABA and glycine mediate fast inhibitory neurotransmission in different
CNS areas and serve pivotal roles in the spinal sensory processing. Under healthy …

The human glycine transporter 1 (GlyT1) regulates glycine-mediated neuronal excitation
and inhibition through the sodium-and chloride-dependent reuptake of glycine,–. Inhibition …

Dendrite branching and spine formation determines the function of morphologically distinct
and specialized neuronal subclasses. However, little is known about the programs …

Glycine transporters are endogenous regulators of the dual functions of glycine, which acts
as a classical inhibitory neurotransmitter at glycinergic synapses and as a modulator of …

Highlights•NMDA receptor (NMDAR) hypofunction contributes to the etiology of
schizophrenia.•Serine racemase, a risk gene for schizophrenia, is expressed primarily in …

Glycine has important neurotransmitter functions at inhibitory and excitatory synapses in the
vertebrate central nervous system. The effective synaptic concentrations of glycine are …