Within a tumor, IL-1β is produced and secreted by various cell types, such as immune cells,
fibroblasts, or cancer cells. The IL1B gene is induced after “priming” of the cells and a …

The consequences of prostate cancer metastasis remain severe, with huge impact on the
mortality and overall quality of life of affected patients. Despite the convoluted interplay and …

Prostate cancer is a highly prevalent form of cancer that is usually slow-developing and
benign. Due to its high prevalence, it is, however, still the second most common cause of …

Introduction Inflammation plays a significant role in various cancers, including lung cancer,
where the inflammatory cytokine IL-1β is often elevated in the tumor microenvironment …

Prostate cancer (PCa) is one of the most fatal diseases in male patients with high bone
metastatic potential. Bone metastasis severely shortens overall survival and brings skeletal …

The propensity of prostate cancer cells to seed the skeleton and then progress into clinically
relevant metastatic tumors is widely recognized and a major cause of morbidity and mortality …

Background The androgen receptor (AR) nuclear transcription factor is a therapeutic target
for prostate cancer (PCa). Unfortunately, patients can develop resistance to AR‐targeted …

Simple Summary Prostate cancer is the most frequently diagnosed non-cutaneous tumor in
men in the Western world. Therapy for non-organ confined prostate cancer includes anti …

Reproductive cancers are malignancies that develop in the reproductive organs. One of the
leading cancers affecting the male reproductive system on a global scale is prostate cancer …

Chronic inflammation promotes prostate cancer (PCa) initiation and progression. We
previously reported that acute intereluekin-1 (IL-1) exposure represses androgen receptor …