Oxaliplatin-induced peripheral neuropathy: clinical features, mechanisms, prevention and treatment

L Kang, Y Tian, S Xu, H Chen - Journal of neurology, 2021 - Springer
Oxaliplatin (OXA) is a commonly used platinum-based chemotherapy drug for colorectal
cancer. OXA-induced peripheral neurotoxcity (OIPN) is a comprehensive adverse reaction of …

Targeting strategies for oxaliplatin-induced peripheral neuropathy: clinical syndrome, molecular basis, and drug development

Y Yang, B Zhao, X Gao, J Sun, J Ye, J Li… - Journal of experimental & …, 2021 - Springer
Oxaliplatin (OHP)-induced peripheral neurotoxicity (OIPN) is a severe clinical problem and
potentially permanent side effect of cancer treatment. For the management of OIPN, accurate …

Phase III trial of doxorubicin plus cisplatin with or without paclitaxel plus filgrastim in advanced endometrial carcinoma: a Gynecologic Oncology Group Study

GF Fleming, VL Brunetto, D Cella, KY Look… - Journal of Clinical …, 2004 - ascopubs.org
Purpose To determine whether the addition of paclitaxel to doxorubicin plus cisplatin
improves overall survival (OS) in women with advanced or recurrent endometrial carcinoma …

Pro-inflammatory signalling PRRopels cisplatin-induced toxicity

IK Domingo, A Latif, AP Bhavsar - International journal of molecular …, 2022 - mdpi.com
Cisplatin is a platinum-based chemotherapeutic that has long since been effective against a
variety of solid-cancers, substantially improving the five-year survival rates for cancer …

Rehabilitation, exercise, and related non-pharmacological interventions for chemotherapy-induced peripheral neurotoxicity: systematic review and evidence-based …

S Tamburin, SB Park, A Schenone, E Mantovani… - Critical reviews in …, 2022 - Elsevier
Pharmacological strategies for chemotherapy-induced peripheral neurotoxicity (CIPN) are
very limited. We systematically reviewed data on rehabilitation, exercise, physical therapy …

Prospectively assessing serum neurofilament light chain levels as a biomarker of paclitaxel‐induced peripheral neurotoxicity in breast cancer patients

S Karteri, J Bruna, AA Argyriou… - Journal of the …, 2022 - Wiley Online Library
Our aim was to assess the significance of measuring serum neurofilament light chain (sNfL)
levels as a biomarker of paclitaxel‐induced peripheral neurotoxicity (PIPN). We …

Axonal degeneration in chemotherapy-induced peripheral neurotoxicity: clinical and experimental evidence

SB Park, A Cetinkaya-Fisgin, AA Argyriou… - Journal of Neurology …, 2023 - jnnp.bmj.com
Multiple pathological mechanisms are involved in the development of chemotherapy-
induced peripheral neurotoxicity (CIPN). Recent work has provided insights into the …

Chemotherapy and peripheral neuropathy

T Li, D Mizrahi, D Goldstein, MC Kiernan, SB Park - Neurological Sciences, 2021 - Springer
Chemotherapy-induced peripheral neurotoxicity (CIPN) is a major dose-limiting side effect of
many anti-cancer agents, including taxanes, platinums, vinca alkaloids, proteasome …

Oxaliplatin-induced peripheral neurotoxicity in colorectal cancer patients: mechanisms, pharmacokinetics and strategies

F Cheng, R Zhang, C Sun, Q Ran, C Zhang… - Frontiers in …, 2023 - frontiersin.org
Oxaliplatin-based chemotherapy is a standard treatment approach for colorectal cancer
(CRC). However, oxaliplatin-induced peripheral neurotoxicity (OIPN) is a severe dose …

Cisplatin-induced peripheral neuropathy is associated with neuronal senescence-like response

A Calls, A Torres-Espin, X Navarro, VJ Yuste… - Neuro …, 2021 - academic.oup.com
Background Cisplatin-induced peripheral neuropathy (CIPN) is a frequent serious dose-
dependent adverse event that can determine dosage limitations for cancer treatment. CIPN …