Application of in vitro metabolism activation in high-throughput screening
In vitro methods which incorporate metabolic capability into the assays allow us to assess
the activity of metabolites from their parent compounds. These methods can be applied into …
the activity of metabolites from their parent compounds. These methods can be applied into …
The proofreading exonuclease of leading-strand DNA polymerase epsilon prevents replication fork collapse at broken template strands
T Ahmad, R Kawasumi, T Taniguchi, T Abe… - Nucleic Acids …, 2023 - academic.oup.com
Leading-strand DNA replication by polymerase epsilon (Polϵ) across single-strand breaks
(SSBs) causes single-ended double-strand breaks (seDSBs), which are repaired via …
(SSBs) causes single-ended double-strand breaks (seDSBs), which are repaired via …
Degradation of azo dye methyl red by Saccharomyces cerevisiae ATCC 9763
S Vatandoostarani, TB Lotfabad, A Heidarinasab… - International …, 2017 - Elsevier
Azo dyes are common dye groups widely used in different industries. Industrial effluents
which contain these dyes pervade water resources and have various known and unknown …
which contain these dyes pervade water resources and have various known and unknown …
XRCC1 counteracts poly (ADP ribose) polymerase (PARP) poisons, olaparib and talazoparib, and a clinical alkylating agent, temozolomide, by promoting the removal …
Base excision repair (BER) removes damaged bases by generating single‐strand breaks
(SSBs), gap‐filling by DNA polymerase β (POLβ), and resealing SSBs. A base‐damaging …
(SSBs), gap‐filling by DNA polymerase β (POLβ), and resealing SSBs. A base‐damaging …
CTF18-RFC contributes to cellular tolerance against chain-terminating nucleoside analogs (CTNAs) in cooperation with proofreading exonuclease activity of DNA …
Chemotherapeutic nucleoside analogs, such as cytarabine (Ara-C), are incorporated into
genomic DNA during replication. Incorporated Ara-CMP (Ara-cytidine monophosphate) …
genomic DNA during replication. Incorporated Ara-CMP (Ara-cytidine monophosphate) …
Molecular modeling study of the genotoxicity of the Sudan I and Sudan II azo dyes and their metabolites
RJ Bienstock, L Perera, MA Pasquinelli - Frontiers in Chemistry, 2022 - frontiersin.org
Azo dyes are defined by the presence of a characteristic N= N group. Sudan I and Sudan II
are synthetic azo dyes that have been used as coloring agents. Although animal toxicity …
are synthetic azo dyes that have been used as coloring agents. Although animal toxicity …
Preliminary in silico studies of the interactions of certain genotoxic azo dyes with different double-stranded DNA conformations
ES İstifli - Colorants, 2022 - mdpi.com
Organic azo dyes, which are widely used in industrial, health and cosmetic fields, pose
genotoxic risks due to their chemical structures; however, the molecular details of the …
genotoxic risks due to their chemical structures; however, the molecular details of the …
Chromatin remodeler ALC1 prevents replication-fork collapse by slowing fork progression
ALC1 (amplified in liver cancer 1), an SNF2 superfamily chromatin-remodeling factor also
known as CHD1L (chromodomain helicase/ATPase DNA binding protein 1-like), is …
known as CHD1L (chromodomain helicase/ATPase DNA binding protein 1-like), is …
SPARTAN promotes genetic diversification of the immunoglobulin-variable gene locus in avian DT40 cells
A Nakazato, K Kajita, M Ooka, R Akagawa, T Abe… - DNA repair, 2018 - Elsevier
Prolonged replication arrest on damaged templates is a cause of fork collapse, potentially
resulting in genome instability. Arrested replication is rescued by translesion DNA synthesis …
resulting in genome instability. Arrested replication is rescued by translesion DNA synthesis …
Pold4 subunit of replicative polymerase δ promotes fork slowing at broken templates
K Kojima, H Ohkubo, R Kawasumi, K Hirota - DNA repair, 2024 - Elsevier
Single-strand breaks (SSBs) are the most frequent type of lesion, and replication across
such lesions leads to double-strand breaks (DSBs). DSBs that arise during replication are …
such lesions leads to double-strand breaks (DSBs). DSBs that arise during replication are …