Anti-DNA antibodies—quintessential biomarkers of SLE

DS Pisetsky - Nature Reviews Rheumatology, 2016 - nature.com
Antibodies that recognize and bind to DNA (anti-DNA antibodies) are serological hallmarks
of systemic lupus erythematosus (SLE) and key markers for diagnosis and disease activity …

Antinuclear antibody testing—misunderstood or misbegotten?

DS Pisetsky - Nature Reviews Rheumatology, 2017 - nature.com
Antinuclear antibodies (ANAs) are a diverse group of autoantibodies that recognize nuclear
macromolecules and their complexes. ANAs represent key biomarkers in the evaluation of …

Mechanisms of kidney injury in lupus nephritis–the role of anti-dsDNA antibodies

S Yung, TM Chan - Frontiers in immunology, 2015 - frontiersin.org
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by a
breakdown of self-tolerance, production of auto-antibodies and immune-mediated injury …

Defining low disease activity in systemic lupus erythematosus

A Polachek, DD Gladman, J Su… - Arthritis care & …, 2017 - Wiley Online Library
Objective To define and identify a group of systemic lupus erythematosus patients with low
disease activity (LDA) and to examine whether LDA is similar to patients in remission and …

Antigen arrays for profiling autoantibody repertoires

B Ayoglu, JM Schwenk, P Nilsson - Bioanalysis, 2016 - Taylor & Francis
Autoantibodies are a key component for the diagnosis, prognosis and monitoring of various
diseases. In order to discover novel autoantibody targets, highly multiplexed assays based …

New perspectives in rheumatology: biomarkers as entry criteria for clinical trials of new therapies for systemic lupus erythematosus: the example of antinuclear …

DS Pisetsky, BH Rovin, PE Lipsky - Arthritis & Rheumatology, 2017 - Wiley Online Library
Systemic lupus erythematosus (SLE) is a prototypical systemic autoimmune disease that
represents a great challenge for current therapy as well as new drug development (1, 2) …

[HTML][HTML] Systemic lupus erythematosus diagnostics in the 'omics' era

C Arriens, C Mohan - International journal of clinical rheumatology, 2013 - ncbi.nlm.nih.gov
Systemic lupus erythematosus is a complex autoimmune disease affecting multiple organ
systems. Currently, diagnosis relies upon meeting at least four out of eleven criteria outlined …

Comparison of current methods for anti‐dsDNA antibody detection and reshaping diagnostic strategies

M Infantino, B Palterer, G Previtali… - Scandinavian …, 2022 - Wiley Online Library
Anti–double‐stranded DNA antibodies (anti‐dsDNA) are considered a specific marker for
systemic lupus erythematosus (SLE). Though the Farr technique was once the reference …

Clinical comparison of QUANTA Flash dsDNA chemiluminescent immunoassay with four current assays for the detection of anti‐dsDNA autoantibodies

M Infantino, F Meacci, C Bentow… - Journal of …, 2015 - Wiley Online Library
Introduction. The objective of the present study was to compare QUANTA Flash dsDNA, a
chemiluminescent immunoassay (CIA) on the BIO‐FLASH, a rapid‐response …

International multi-center evaluation of a novel chemiluminescence assay for the detection of anti-dsDNA antibodies

C Bentow, G Lakos, P Martis, E Wahl, M Garcia… - Lupus, 2016 - journals.sagepub.com
Objective: Anti-double stranded desoxyribonucleic acid (anti-dsDNA) antibodies are
considered fairly specific for systemic lupus erythematosus (SLE) and their quantification is …