The immune response in multiple sclerosis

S Rodríguez Murúa, MF Farez… - Annual Review of …, 2022 - annualreviews.org
Multiple sclerosis (MS) is a chronic autoimmune, inflammatory, and neurodegenerative
disease that affects the central nervous system (CNS). MS is characterized by immune …

JAK inhibition as a therapeutic strategy for immune and inflammatory diseases

DM Schwartz, Y Kanno, A Villarino, M Ward… - Nature reviews Drug …, 2017 - nature.com
The discovery of cytokines as key drivers of immune-mediated diseases has spurred efforts
to target their associated signalling pathways. Janus kinases (JAKs) are essential signalling …

How does the immune system enter the brain?

JA Mapunda, H Tibar, W Regragui… - Frontiers in …, 2022 - frontiersin.org
Multiple Sclerosis (MS) is considered the most frequent inflammatory demyelinating disease
of the central nervous system (CNS). It occurs with a variable prevalence across the world. A …

Molecular biomarkers in multiple sclerosis

T Ziemssen, K Akgün, W Brück - Journal of neuroinflammation, 2019 - Springer
Multiple sclerosis (MS) is an inflammatory-neurodegenerative disease of the central nervous
system presenting with significant inter-and intraindividual heterogeneity. However, the …

Memory B cells are major targets for effective immunotherapy in relapsing multiple sclerosis

D Baker, M Marta, G Pryce, G Giovannoni… - …, 2017 - thelancet.com
Although multiple sclerosis (MS) is considered to be a CD4, Th17-mediated autoimmune
disease, supportive evidence is perhaps circumstantial, often based on animal studies, and …

Involvement of cytotoxic Eomes-expressing CD4+ T cells in secondary progressive multiple sclerosis

BJE Raveney, W Sato, D Takewaki… - Proceedings of the …, 2021 - National Acad Sciences
Multiple sclerosis (MS), a putative autoimmune disease of the central nervous system (CNS),
commonly presents as relapsing-remitting MS (RRMS), characterized by recurrent episodes …

Update on disease-modifying therapies for multiple sclerosis

DL Vargas, WR Tyor - Journal of Investigative Medicine, 2017 - journals.sagepub.com
Multiple sclerosis (MS) is an autoimmune, demyelinating disease of the central nervous
system (CNS). It predominantly affects young women and is one of the most common causes …

Multiple sclerosis: inflammatory and neuroglial aspects

G Papiri, G D'Andreamatteo, G Cacchiò, S Alia… - Current Issues in …, 2023 - mdpi.com
Multiple sclerosis (MS) represents the most common acquired demyelinating disorder of the
central nervous system (CNS). Its pathogenesis, in parallel with the well-established role of …

Bruton's tyrosine kinase inhibition in multiple sclerosis

R Schneider, J Oh - Current neurology and neuroscience reports, 2022 - Springer
Abstract Purpose of Review Multiple sclerosis (MS) is an inflammatory disease of the central
nervous system (CNS) with a chronic and often progressive disease course. The current …

Current and emerging uses of statins in clinical therapeutics: a review

JT Davies, SF Delfino, CE Feinberg… - Lipid …, 2016 - journals.sagepub.com
Statins, a class of cholesterol-lowering medications that inhibit 3-hydroxy-3-methyl-glutaryl-
coenzyme A reductase, are commonly administered to treat atherosclerotic cardiovascular …