Contingent upon concentration, reactive oxygen species (ROS) influence cancer evolution
in apparently contradictory ways, either initiating/stimulating tumorigenesis and supporting …

Glutathione (GSH), a tripeptide particularly concentrated in the liver, is the most important
thiol reducing agent involved in the modulation of redox processes. It has also been …

Stressful life events produce a state of vulnerability to depression in some individuals. The
mechanisms that contribute to vulnerability to depression remain poorly understood. A rat …

The human brain generally remains structurally and functionally sound for many decades,
despite the post-mitotic and non-regenerative nature of neurons. This is testament to the …

Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor that positively
regulates the basal and inducible expression of a large battery of cytoprotective genes …

With oxidative injury as well as in some solid tumors and myeloid leukemia cells, heme
oxygenase-1 (HO-1), the anti-oxidant, anti-inflammatory, and anti-apoptotic microsomal …

N-methyl-d-aspartate receptors (NMDARs) are ligand-gated ion channels
('ionotropic'receptors) activated by the major excitatory neurotransmitter, l-glutamate. While …

Reactive oxygen species (ROS) activate NF-E2-related transcription factor 2 (Nrf2), a key
transcriptional regulator driving antioxidant gene expression and protection from oxidant …

Cancer heterogeneity constitutes the major source of disease progression and therapy
failure. Tumors comprise functionally diverse subpopulations, with cancer stem cells (CSCs) …

Ferulic acid, a natural phytochemical has gained importance as a potential therapeutic
agent by virtue of its easy commercial availability, low cost and minimal side-effects. It is a …