Multicellular spheroids are three dimensional in vitro microscale tissue analogs. The current
article examines the suitability of spheroids as an in vitro platform for testing drug delivery …

“Organ‐on‐a‐chip” systems integrate microengineering, microfluidic technologies, and
biomimetic principles to create key aspects of living organs faithfully, including critical …

Despite major scientific, medical and technological advances over the last few decades, a
cure for cancer remains elusive. The disease initiation is complex, and including initiation …

Abnormal vascularization of solid tumours results in the development of microenvironments
deprived of oxygen and nutrients that harbour slowly growing and metabolically stressed …

In cancer research and personalized medicine, new tissue culture models are needed to
better predict the response of patients to therapies. With a concern for the small volume of …

Background: Fat grafting is now widely used in plastic surgery. Long-term graft retention can
be unpredictable. Fat grafts must obtain oxygen via diffusion until neovascularization occurs …

The heterogeneity of cellular microenvironments in tumors severely limits the efficacy of
most cancer therapies. We have designed a microfluidic device that mimics the …

Solid tumors, whether in vitro or in vivo, are not an undifferentiated mass of cells. They
include necrotic regions, regions of cells that are in a quiescent state (either slowly growing …

Oxygen levels in cancerous tissue can have a significant effect on treatment response:
hypoxic tissue is both more radioresistant and more chemoresistant than well-oxygenated …

We model the metabolism and behaviour of a developing cancer tumour in the context of its
microenvironment, with the aim of elucidating the consequences of altered energy …