Colorectal cancer (CRC) is the third cause of cancer death worldwide. Although, in some
cases, treatment can increase patient survival and reduce cancer recurrence, in many …

Evolutionarily conserved Notch plays a critical role in embryonic development and cellular
self-renewal. It has both tumour suppressor and oncogenic activity, the latter of which is …

Cancer is one of the dreadful diseases worldwide. Surgery, radiation and chemotherapy, are
the three basic standard modes of cancer treatment. However, difficulties in cancer treatment …

Non-genetic mechanisms have recently emerged as important drivers of anticancer drug
resistance. Among these, the drug tolerant persister (DTP) cell phenotype is attracting more …

Colorectal cancer (CRC) is a common gastrointestinal malignancy with high morbidity and
fatality. Chemotherapy, as traditional therapy for CRC, has exerted well antitumor effect and …

Hepatocellular carcinoma (HCC) is a fatal disease with limited therapeutic choices. The
stroma-rich tumor microenvironment hinders the in vivo delivery of most nanomedicines …

Colorectal cancer (CRC) is the third most commonly detected cancer with a serious global
health issue. The rates for incidence and mortality for CRC are alarming, especially since …

Simple Summary A subset of colorectal cancers (CRCs) is characterized by a mismatch
repair deficiency that is frequently associated with microsatellite instability (MSI). The …

Background Colorectal cancer (CRC) is one of the most common gastrointestinal
malignancies with a significant mortality rate. Despite the great advances in cancer …

Homeodomain-interacting protein kinase 2 (HIPK2) is a serine-threonine kinase that
phosphorylates and regulates a plethora of transcriptional regulators and chromatin …