Motor and non-motor features of Parkinson's disease–a review of clinical and experimental studies

M MS Lima, E F. Martins… - CNS & Neurological …, 2012 - benthamdirect.com
Classically, Parkinson's disease (PD) is considered to be a motor system affliction and its
diagnosis is based on the presence of a set of cardinal motor signs (eg rigidity, bradykinesia …

The path to progress preclinical studies of age-related neurodegenerative diseases: a perspective on rodent and hiPSC-derived models

G MacDougall, LY Brown, B Kantor, O Chiba-Falek - Molecular Therapy, 2021 - cell.com
Alzheimer's disease (AD) and Parkinson's disease (PD) are the two most prevalent age-
related neurodegenerative diseases, and currently no effective clinical treatments exist for …

Central Role of Hypothalamic Circuits for Acupuncture's Anti‐Parkinsonian Effects

JY Oh, H Lee, SY Jang, H Kim, G Park… - Advanced …, 2024 - Wiley Online Library
Despite clinical data stretching over millennia, the neurobiological basis of the effectiveness
of acupuncture in treating diseases of the central nervous system has remained elusive …

Social enrichment attenuates nigrostriatal lesioning and reverses motor impairment in a progressive 1-methyl-2-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) mouse …

NRS Goldberg, V Fields, L Pflibsen, MF Salvatore… - Neurobiology of …, 2012 - Elsevier
Environmental enrichment has been shown to be both neuroprotective and neurorestorative
in 1-methyl-2-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) mouse models of Parkinson's …

Current status of tyrosine hydroxylase in management of Parkinson's disease

A Petithomme Feve - … (Formerly Current Drug Targets-CNS & …, 2012 - ingentaconnect.com
Tyrosine hydroxylase (TH) is the rate limiting enzyme responsible for converting tyrosine to L-
DOPA in the dopamine synthesis pathway. The pathophysiology of Parkinson's disease …

Escin, a novel triterpene, mitigates chronic MPTP/p-induced dopaminergic toxicity by attenuating mitochondrial dysfunction, oxidative stress, and apoptosis

GP Selvakumar, T Manivasagam, KR Rekha… - Journal of Molecular …, 2015 - Springer
Parkinson's disease (PD) is a common, chronic, and debilitating neurodegenerative disorder
characterized by progressive loss of nigrostriatal dopaminergic neurons due to unknown …

Executive function deficits and glutamatergic protein alterations in a progressive 1‐methyl‐4‐phenyl‐1, 2, 3, 6‐tetrahydropyridine mouse model of Parkinson's disease

L Pflibsen, KA Stang, MD Sconce… - Journal of …, 2015 - Wiley Online Library
Changes in executive function are at the root of most cognitive problems associated with
Parkinson's disease. Because dopaminergic treatment does not necessarily alleviate deficits …

Multiple intranigral unilateral LPS infusion protocol generates a persistent cognitive impairment without cumulative dopaminergic impairment

AM Delattre, B Carabelli, MA Mori… - CNS & Neurological …, 2013 - benthamdirect.com
Inflammation in Parkinson's disease (PD) is a continuous process and might be implicated in
the progression of neuronal degeneration. Taking this into account, we proposed a new …

Discrete projections from MCH neurons mediate anti-parkinsonian effects of acupuncture

JY Oh, H Lee, SY Jang, H Kim, G Park, A Serikov… - bioRxiv, 2023 - biorxiv.org
Parkinson's disease (PD) presents with typical motor dysfunction and non-motor symptoms,
including memory loss. Although acupuncture is suggested as an alternative therapy for PD …