T cells are the main effector cells in immune response against tumors. The activation of T
cells is regulated by the innate immune system through positive and negative costimulatory …

The coinhibitory molecule B7-H4, an important member of the B7 family, is abnormally
expressed in tumors, inflammation and autoimmune diseases. B7-H4 negatively regulates T …

Purpose: We evaluated the activity of AZD8205, a B7-H4–directed antibody–drug conjugate
(ADC) bearing a novel topoisomerase I inhibitor (TOP1i) payload, alone and in combination …

Tumor immunotherapy has attracted more and more attention nowadays, and multiple
clinical trials have confirmed its effect in a variety of solid tumors. Immune checkpoint …

Background As a negative co-stimulatory molecule of the B7 family, B7-H4 has recently
attracted increased attention. However, the clinical value of B7-H4 in colorectal cancer …

Background Craniopharyngioma (CP) is a common refractory tumor of the central nervous
system. However, little is known about the expression and clinical significance of B7 family …

Background The objective of this investigation was to characterize the expression landscape
of immune regulatory molecules programmed death-ligand-1 (PD-L1, B7-H1) and B7-H4 in …

Background SGN-B7H4V is a novel investigational vedotin antibody–drug conjugate (ADC)
comprising a B7-H4-directed human monoclonal antibody conjugated to the cytotoxic …

Background The expression of the immunoregulatory protein B7-H4 has been reported in
many types of cancer, including breast cancer. However, its role in triple-negative breast …

Immunotherapy stands as a critical and auspicious therapeutic approach in the fight against
cancer nowadays. Immune checkpoint inhibitors, in particular, have garnered widespread …